Singh S D, Gupta S, Shukla H S, Khanna S, Singh R G
Indian J Pathol Microbiol. 1989 Apr;32(2):125-32.
A total 17 cases of carcinoma oesophagus were studied in a period of 2 years. Ten patients (58.82%) were males and rest were females. Maximum cases (64.70%) were seen in 5th and 6th decades. Majority of the patients belonged to low socio-economic group (47.05%) followed by middle socio-economic group (41.17%). Dysphagia was present in all cases, followed by weight loss 52.94% and other symptoms. Cancer was equally distributed in middle third and lower third of the oesophagus (41.18% in each group) only in 3 cases it was in upper third of the oesophagus. Histologically 70.5% tumours were squamous cell carcinoma, 17.64% were adenocarcinoma and 11.76% were undifferentiated carcinoma. Surrounding epithelium in 17.64 per cent cases showed chronic oesophagitis, 4 cases (23.52%) showed acanthosis and dysplasia, and two cases revealed carcinoma in situ. Hence findings of oesophagitis, acanthosis, dysplasia, carcinoma in situ suggest that oesophagitis and acanthosis may be considered as precancerous lesions.
在两年时间里共研究了17例食管癌病例。10例患者（58.82%）为男性，其余为女性。最大病例数（64.70%）出现在50至60岁年龄段。大多数患者属于低社会经济群体（47.05%），其次是中等社会经济群体（41.17%）。所有病例均有吞咽困难，其次是体重减轻（52.94%）及其他症状。癌症在食管中三分之一和下三分之一部位分布均等（每组41.18%），仅3例位于食管上三分之一。组织学上，70.5%的肿瘤为鳞状细胞癌，17.64%为腺癌，11.76%为未分化癌。17.64%的病例周围上皮显示慢性食管炎，4例（23.52%）显示棘皮症和发育异常，2例显示原位癌。因此，食管炎、棘皮症、发育异常、原位癌的发现表明食管炎和棘皮症可能被视为癌前病变。
