Miki Satomi, Inokuma Ken-Ichi, Takashima Miyuki, Nishida Mitsuho, Sasaki Yoko, Ushijima Mitsuyasu, Suzuki Jun-Ichiro, Morihara Naoaki
Drug Discovery Laboratory, Wakunaga Pharmaceutical Co. Ltd., Hiroshima, Japan.
Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600797. Epub 2017 Feb 21.
In this study, we investigated the effect of aged garlic extract (AGE) on the high level of blood glucose in Tsumura Suzuki Obese-Diabetes (TSOD) mice.
TSOD mice were fed standard diet with or without 2% AGE for 19 weeks. AGE treatment lowered the blood glucose level and significantly reduced the plasma level of glycated albumin in TSOD mice as compared with those without AGE treatment. In addition, AGE treatment increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the adipose tissue, liver and muscle that played an important role in the maintenance of insulin sensitivity. Moreover, AGE treatment also suppressed the mRNA expression of fatty acid synthase, a known factor regulated by AMPK, and monocyte chemoattractant protein 1, one of the representative inflammatory chemokines, in the adipose tissue but not in the liver.
AGE treatment suppresses the increase of plasma glycated albumin level in TSOD mice and this effect is accompanied by the activation of AMPK in adipose tissue, and suggests that AGE may play a potential role in the prevention and treatment of type 2 diabetes.
在本研究中，我们调查了 aged garlic extract (AGE， aged garlic extract即“蒜龄提取物”) 对津村铃木肥胖糖尿病 (TSOD) 小鼠高血糖水平的影响。
给TSOD小鼠喂食含或不含2% AGE的标准饮食19周。与未接受AGE处理的小鼠相比，AGE处理降低了TSOD小鼠的血糖水平，并显著降低了糖化白蛋白的血浆水平。此外，AGE处理增加了脂肪组织、肝脏和肌肉中磷酸化AMP活化蛋白激酶 (AMPK) 的水平，AMPK在维持胰岛素敏感性方面发挥着重要作用。此外，AGE处理还抑制了脂肪组织中脂肪酸合酶（一种已知受AMPK调节的因子）和单核细胞趋化蛋白1（一种代表性的炎症趋化因子）的mRNA表达，但在肝脏中未观察到这种抑制作用。
AGE处理可抑制TSOD小鼠血浆糖化白蛋白水平的升高，且这种作用伴随着脂肪组织中AMPK的激活，这表明AGE可能在2型糖尿病的预防和治疗中发挥潜在作用。
