铑催化炔基噻二唑的分子内重排反应实现 5,n-稠合噻吩。
Rhodium-Catalyzed Intramolecular Transannulation Reaction of Alkynyl Thiadiazole Enabled 5,n-Fused Thiophenes.
机构信息
National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University , Chuncheon 24341, Republic of Korea.
出版信息
J Org Chem. 2017 Feb 3;82(3):1437-1447. doi: 10.1021/acs.joc.6b02614. Epub 2017 Jan 25.
A method for the synthesis of a wide range of fused thiophenes, including those fused with lactams, lactones, or cyclic ethers, was developed from a rhodium-catalyzed intramolecular transannulation reaction of alkynyl thiadiazoles. This transannulation reaction provides an efficient platform for the construction of a variety of 5,n-fused thiophenes from readily available starting materials together with the release of molecular nitrogen.
开发了一种从炔基噻二唑的铑催化分子内环化反应出发，合成广泛的稠合噻吩的方法，包括与内酰胺、内酯或环醚稠合的噻吩。这种环化反应为从易得的起始原料构建各种 5,n-稠合噻吩提供了一个有效的平台，同时释放出分子氮。
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