1,2,3-噻二唑衍生的铑硫杂环戊二烯卡宾促进多取代噻吩的模块化合成。
Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis of Multisubstituted Thiophenes.
机构信息
Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607-7061, United States.
出版信息
Org Lett. 2016 Apr 15;18(8):1804-7. doi: 10.1021/acs.orglett.6b00541. Epub 2016 Mar 25.
PMID:27015356
Abstract
The rhodium-catalyzed transannulation reaction between 1,2,3-thiadiazoles and alkynes, proceeding via intermediacy of the previously unknown Rh thiavinyl carbene, toward a highly efficient and regioselective synthesis of up to fully substituted thiophenes is described.
摘要
铑催化的 1,2,3-噻二唑和炔烃之间的transannulation 反应，通过先前未知的 Rh 硫杂乙烯碳烯中间体进行，实现了高效和区域选择性的完全取代噻吩的合成。
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