Department of Cardiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China.
School of Pharmaceutical Engineering &Life Science, Changzhou University, Changzhou 213164, P. R. China.
Sci Rep. 2017 Jan 11;7:40172. doi: 10.1038/srep40172.
Here we report a supramolecular hydrogel based on Gd(III)-peptide complexes with dramatically enhanced magnetic resonance (MR) performance. The hydrogelations were formed by adding Gd(III) ion to the nanofiber dispersion of self-assembling peptides naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp (Nap-GFFYGRGD) or naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu (Nap-GFFYGRGE). We further showed that, by adjusting the molar ratio between Gd(III) and the corresponding peptide, the mechanical property of resulting gels could be fine-tuned. The longitudinal relaxivity (r) of the Nap-GFFYGRGE-Gd(III) was 58.9 mM S, which to our knowledge is the highest value for such peptide-Gd(III) complexes so far. Such an enhancement of r value could be applied for enzyme detection in aqueous solutions and cell lysates.
在这里，我们报道了一种基于 Gd(III)-肽配合物的超分子水凝胶，其磁共振（MR）性能得到了显著增强。水凝胶的形成是通过将 Gd(III)离子添加到自组装肽萘基-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp（Nap-GFFYGRGD）或萘基-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu（Nap-GFFYGRGE）的纳米纤维分散体中。我们进一步表明，通过调整 Gd(III)与相应肽之间的摩尔比，可以精细调节所得凝胶的机械性能。Nap-GFFYGRGE-Gd(III)的纵向弛豫率（r）为 58.9 mM S，据我们所知，这是迄今为止此类肽-Gd(III)配合物的最高值。这种 r 值的增强可用于检测水溶液和细胞裂解物中的酶。
