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自组装肽定量分析的最新进展。

Recent progress in quantitative analysis of self-assembled peptides.

作者信息

Cai Xiaoyao, Xu Wei, Ren Chunhua, Zhang Liping, Zhang Congrou, Liu Jianfeng, Yang Cuihong

机构信息

Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China.

Department of Pathology Characteristic Medical Center of Chinese People's Armed Police Forces Tianjin P. R. China.

出版信息

Exploration (Beijing). 2024 Jan 23;4(4):20230064. doi: 10.1002/EXP.20230064. eCollection 2024 Aug.

DOI:10.1002/EXP.20230064
PMID:39175887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335468/
Abstract

Self-assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. Over the past decades, substantial progress and breakthroughs have been made in designing self-assembled peptides with multifaceted biomedical applications. The techniques for quantitative analysis, including imaging-based quantitative techniques, chromatographic technique and computational approach (molecular dynamics simulation), are becoming powerful tools for exploring the structure, properties, biomedical applications, and even supramolecular assembly processes of self-assembled peptides. However, a comprehensive review concerning these quantitative techniques remains scarce. In this review, recent progress in techniques for quantitative investigation of biostability, cellular uptake, biodistribution, self-assembly behaviors of self-assembled peptide etc., are summarized. Specific applications and roles of these techniques are highlighted in detail. Finally, challenges and outlook in this field are concluded. It is believed that this review will provide technical guidance for researchers in the field of peptide-based materials and pharmaceuticals, and facilitate related research for newcomers in this field.

摘要

自组装肽因其优异的生物相容性和多样的功能而成为重要的生物材料之一。在过去几十年中，在设计具有多方面生物医学应用的自组装肽方面取得了重大进展和突破。包括基于成像的定量技术、色谱技术和计算方法（分子动力学模拟）在内的定量分析技术，正成为探索自组装肽的结构、性质、生物医学应用乃至超分子组装过程的有力工具。然而，关于这些定量技术的全面综述仍然很少。在这篇综述中，总结了自组装肽的生物稳定性、细胞摄取、生物分布、自组装行为等定量研究技术的最新进展。详细强调了这些技术的具体应用和作用。最后，总结了该领域的挑战和展望。相信这篇综述将为基于肽的材料和药物领域的研究人员提供技术指导，并促进该领域新手的相关研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/70970c43f2f5/EXP2-4-20230064-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/938e39ccb4e3/EXP2-4-20230064-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/9d35359a7ea9/EXP2-4-20230064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/55bbee3ecca5/EXP2-4-20230064-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/e8dfdfbc5c23/EXP2-4-20230064-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/938e39ccb4e3/EXP2-4-20230064-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ad/11335468/6f809f56af4c/EXP2-4-20230064-g013.jpg
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