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本文引用的文献

1
Divergent reaction pathways in gold-catalyzed cycloisomerization of 1,5-enynes containing a cyclopropane ring: dramatic substituent and temperature effects.含环丙烷环的1,5-烯炔在金催化环异构化反应中的不同反应途径：显著的取代基和温度效应
Chem Sci. 2016 Jul 1;7(7):4318-4328. doi: 10.1039/c6sc00058d. Epub 2016 Mar 4.
2
Gold-Catalyzed Vinyl Ether Hydroalkynylation: An Alternative Pathway for the Gold-Catalyzed Intermolecular Reaction of Alkenes and Alkynes.金催化乙烯基醚氢炔基化反应：烯烃和炔烃的金催化分子间反应的另一种途径。
Org Lett. 2016 Dec 16;18(24):6336-6339. doi: 10.1021/acs.orglett.6b03228. Epub 2016 Nov 29.
3
Regioselective Amine-Borane Cyclization: Towards the Synthesis of 1,2-BN-3-Cyclohexene by Copper-Assisted Triazole/Gold Catalysis.区域选择性胺-硼烷环化反应：通过铜辅助三唑/金催化合成 1,2-BN-3-环己烯。
Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11582-6. doi: 10.1002/anie.201604986. Epub 2016 Aug 17.
4
Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction.金催化串联反应合成2-芳基取代喹啉的汇聚式合成
Chem Pharm Bull (Tokyo). 2016;64(7):824-9. doi: 10.1248/cpb.c16-00193.
5
Intermolecular Homopropargyl Alcohol Addition to Alkyne and a Sequential 1,6-Enyne Cycloisomerization with Triazole-Gold Catalyst.分子间炔丙醇与炔烃的加成反应及三氮唑-金催化剂的串联 1,6-烯炔环异构化反应。
J Am Chem Soc. 2016 Mar 30;138(12):3994-7. doi: 10.1021/jacs.6b00882. Epub 2016 Mar 17.
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Gold catalysis in total synthesis - recent achievements.金催化在全合成中的应用——最新进展。
Chem Soc Rev. 2016 Mar 7;45(5):1331-67. doi: 10.1039/c5cs00721f.
7
Gold-Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols.金催化的通过炔基苯并二氢吡喃酮的氧化环扩张合成色酮及其类似物。
Org Lett. 2015 Dec 4;17(23):5926-9. doi: 10.1021/acs.orglett.5b03160. Epub 2015 Nov 24.
8
Gold-Catalyzed Ring Expansion of Alkynyl Heterocycles through 1,2-Migration of an Endocyclic Carbon-Heteroatom Bond.金催化炔基杂环通过环内碳-杂原子键的1,2-迁移进行扩环反应。
Chemistry. 2015 Dec 14;21(51):18571-5. doi: 10.1002/chem.201504165. Epub 2015 Nov 5.
9
Divergent Gold(I)-Catalyzed Skeletal Rearrangements of 1,7-Enynes.不同的金（I）催化的1,7-烯炔的骨架重排反应
Chemistry. 2015 Sep 21;21(39):13526-30. doi: 10.1002/chem.201502843.
10
Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and -cinnolines.金催化1,6 - 二炔酯与烯烃和重氮化合物环异构化及狄尔斯 - 阿尔德反应生成氢化萘和噌啉
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通过发散性金催化作用探索同型炔丙醇与末端炔烃之间分子间缩合的替代反应途径。

Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis.

作者信息

Smith Courtney A, Motika Stephen E, Wojtas Lukasz, Shi Xiaodong

机构信息

Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.

出版信息

Chem Commun (Camb). 2017 Feb 16;53(15):2315-2318. doi: 10.1039/c6cc09794d.

DOI:10.1039/c6cc09794d
PMID:28074975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5313346/
Abstract

An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf, an efficient Au-catalyzed cyclization-alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates.

摘要

报道了一种炔醇与末端炔烃的分子间缩合反应。使用IPrAuNTf，一种高效的金催化环化-炔基化策略能够以中等至优异的产率（高达94%）得到(2-芳基炔基)环醚。该策略通过对环醚底物进行连续的金催化扩环反应扩展至官能化2,3-二氢氧杂环庚三烯的合成。