寨卡病毒NS2B-NS3蛋白酶的新高分辨率晶体结构
The New High Resolution Crystal Structure of NS2B-NS3 Protease of Zika Virus.
作者信息
Badshah Syed Lal, Naeem Abdul, Mabkhot Yahia
机构信息
Department of Chemistry, Islamia College University, Peshawar 25120, Khyber Pukhtoonkhwa, Pakistan.
National Center of Excellence in Physical Chemistry, University of Peshawar, Peshawar 25120, Khyber Pukhtoonkhwa, Pakistan.
出版信息
Viruses. 2017 Jan 10;9(1):7. doi: 10.3390/v9010007.
Zika virus (ZIKV) is the cause of a significant viral disease affecting humans, which has spread throughout many South American countries and has also become a threat to Southeastern Asia. This commentary discusses the article "Crystal structure of unlinked NS2B-NS3 protease from Zika virus" published recently in the journal by Zhang et al. of Nanyang Technological University, Singapore. They resolved a 1.58 Å resolution structure of the NS2B-NS3 protease of ZIKV and demonstrated how peptide and non-peptide inhibitors interact with this structure, along with the different conformational states that were observed. This protease crystal structure offers new opportunities for the design and development of novel antiviral drugs used for the treatment and control of ZIKV.
寨卡病毒（ZIKV）是一种引发严重人类病毒性疾病的病原体，它已在许多南美国家传播，并且对东南亚地区也构成了威胁。本评论文章讨论了新加坡南洋理工大学张等人近期发表在某期刊上的题为《寨卡病毒非连接NS2B-NS3蛋白酶的晶体结构》的文章。他们解析出了寨卡病毒NS2B-NS3蛋白酶分辨率为1.58 Å的结构，并展示了肽类和非肽类抑制剂如何与该结构相互作用，以及所观察到的不同构象状态。这种蛋白酶晶体结构为设计和开发用于治疗及控制寨卡病毒的新型抗病毒药物提供了新的机会。
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