Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière Hospital, DHU I2B, AP-HP, Paris, France.
INSERM U974, UPMC Sorbonne Universities, Paris, France.
Neuropathol Appl Neurobiol. 2017 Feb;43(1):62-81. doi: 10.1111/nan.12380.
Inflammatory myopathies comprise a multitude of diverse diseases, most often occurring in complex clinical settings. To ensure accurate diagnosis, multidisciplinary expertise is required. Here, we propose a comprehensive myositis classification that incorporates clinical, morphological and molecular data as well as autoantibody profile. This review focuses on recent advances in myositis research, in particular, the correlation between autoantibodies and morphological or clinical phenotypes that can be used as the basis for an 'integrated' classification system.
炎性肌病包含多种不同的疾病，大多数情况下发生在复杂的临床环境中。为了确保准确诊断，需要多学科专业知识。在这里，我们提出了一种综合的肌炎分类，将临床、形态学和分子数据以及自身抗体谱结合在一起。本综述重点介绍了肌炎研究的最新进展，特别是自身抗体与形态学或临床表型之间的相关性，这些相关性可作为“综合”分类系统的基础。
