Sujenthiran Arunan, Charman Susan C, Parry Matthew, Nossiter Julie, Aggarwal Ajay, Dasgupta Prokar, Payne Heather, Clarke Noel W, Cathcart Paul, van der Meulen Jan
Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK.
London School of Hygiene and Tropical Medicine, London, UK.
BJU Int. 2017 Aug;120(2):219-225. doi: 10.1111/bju.13770. Epub 2017 Feb 8.
To develop and validate a surgical performance indicator based on severe urinary complications that require an intervention within 2 years of radical prostatectomy (RP), identified in hospital administrative data.
Men who underwent RP between 2008 and 2012 in England were identified using hospital administrative data. A transparent coding framework based on procedure codes was developed to identify severe urinary complications which were grouped into 'stricture', 'incontinence' and 'other'. Their validity as a performance indicator was assessed by evaluating the consistency with diagnosis codes and association with patient and surgical characteristics. Kaplan-Meier methods were used to assess time to first occurrence and multivariable logistic regression was used to estimate adjusted odds ratios (ORs) for patient and surgical characteristics.
A total of 17 299 men were included, of whom 2695 (15.6%) experienced at least one severe urinary complication within 2 years. High proportions of men with a complication had relevant diagnosis codes: 86% for strictures and 93% for incontinence. Urinary complications were more common in men from poorer socio-economic backgrounds (OR comparing lowest with highest quintile: 1.45; 95% confidence interval [CI] 1.26-1.67) and in those with prolonged length of hospital stay (OR 1.54, 95% CI 1.40-1.69), and were less common in men who underwent robot-assisted surgery (OR 0.65, 95% CI 0.58-0.74).
These results show that severe urinary complications identified in administrative data provide a medium-term performance indicator after RP. They can be used for research assessing outcomes of treatment methods and for service evaluation comparing performance of prostate cancer surgery providers.
基于严重泌尿系统并发症制定并验证一项手术性能指标,该指标需在前列腺癌根治术(RP)后2年内进行干预,通过医院管理数据识别。
利用医院管理数据识别2008年至2012年在英格兰接受RP的男性患者。制定基于手术编码的透明编码框架,以识别严重泌尿系统并发症,这些并发症分为“狭窄”、“尿失禁”和“其他”。通过评估与诊断编码的一致性以及与患者和手术特征的关联,评估其作为性能指标的有效性。采用Kaplan-Meier方法评估首次发生时间,采用多变量逻辑回归估计患者和手术特征的调整优势比(OR)。
共纳入17299名男性,其中2695名(15.6%)在2年内经历了至少一种严重泌尿系统并发症。发生并发症的男性中,很大比例有相关诊断编码:狭窄为86%,尿失禁为93%。泌尿系统并发症在社会经济背景较差的男性中更常见(最低五分位数与最高五分位数比较的OR:1.45;95%置信区间[CI]1.26 - 1.67),在住院时间延长的男性中也更常见(OR 1.54,95% CI 1.40 - 1.69),而在接受机器人辅助手术的男性中较少见(OR 0.65,95% CI 0.58 - 0.74)。
这些结果表明,管理数据中识别出的严重泌尿系统并发症可作为RP后的中期性能指标。它们可用于评估治疗方法结果的研究以及比较前列腺癌手术提供者性能的服务评估。