基质的病理生物学——蛋白聚糖和肝素酶在健康和疾病中的核心作用。

Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.

机构信息

Biochemistry Laboratory, Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Department of Chemistry, University of Patras, Greece.

出版信息

FEBS J. 2017 Jan;284(1):7-9. doi: 10.1111/febs.13945.

DOI:10.1111/febs.13945

PMID:28075546

Abstract

This thematic minireview series highlights new concepts in matrix pathobiology. The reviews in this series cover the roles of the two matrix proteoglycans, decorin and biglycan, in inflammation and autophagy, the various functions of syndecans in cancer development and prognosis and the recently discovered mechanisms underlying the multiple roles of heparanase in cancer progression, inflammation, and autophagy.

摘要

本专题综述系列重点介绍了基质病理生物学的新概念。本系列中的综述涵盖了两种基质蛋白聚糖，即 decorin 和 biglycan，在炎症和自噬中的作用、 syndecans 在癌症发展和预后中的各种功能以及最近发现的肝素酶在癌症进展、炎症和自噬中的多种作用的潜在机制。