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富含亮氨酸的小分子蛋白聚糖在宿主免疫和肾脏疾病中的作用

Small leucine rich proteoglycans in host immunity and renal diseases.

作者信息

Zou Wei, Wan Junhui, Li Min, Xing Juanjuan, Chen Qi, Zhang Zhi, Gong Yi

机构信息

Department of Infectious Diseases, The 1st Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.

Department of Gynecology and Obstetrics, The 1st Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

出版信息

J Cell Commun Signal. 2019 Dec;13(4):463-471. doi: 10.1007/s12079-018-0489-8. Epub 2018 Oct 25.

DOI:10.1007/s12079-018-0489-8
PMID:30357553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6946788/
Abstract

The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.

摘要

富含亮氨酸的小分子蛋白聚糖（SLRPs）在结构上由蛋白核心和各种糖胺聚糖侧链组成，根据共同的结构和功能特性分为五类。除了作为细胞外基质（ECM）的重要结构成分外，SLRPs还参与了信号转导和宿主免疫反应的复杂网络。本综述的重点是宿主免疫中的SLRPs。由于宿主免疫在肾脏疾病的发病机制中起重要作用，因此也将讨论SLRPs在这类疾病中的作用。

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