• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Small leucine rich proteoglycans in host immunity and renal diseases.富含亮氨酸的小分子蛋白聚糖在宿主免疫和肾脏疾病中的作用
J Cell Commun Signal. 2019 Dec;13(4):463-471. doi: 10.1007/s12079-018-0489-8. Epub 2018 Oct 25.
2
The matricellular functions of small leucine-rich proteoglycans (SLRPs).小富含亮氨酸的蛋白聚糖 (SLRPs) 的基质细胞功能。
J Cell Commun Signal. 2009 Dec;3(3-4):323-35. doi: 10.1007/s12079-009-0066-2. Epub 2009 Oct 2.
3
Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key?揭示退行性椎间盘疾病再生治疗的分子靶点:富含亮氨酸的小蛋白聚糖是否是关键?
Spine J. 2021 Jan;21(1):5-19. doi: 10.1016/j.spinee.2020.04.011. Epub 2020 Apr 25.
4
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.富含亮氨酸小分子蛋白聚糖的生物学功能:从遗传学到信号转导
J Biol Chem. 2008 Aug 1;283(31):21305-9. doi: 10.1074/jbc.R800020200. Epub 2008 May 6.
5
The role of small leucine-rich proteoglycans in osteoarthritis pathogenesis.富含亮氨酸小分子蛋白聚糖在骨关节炎发病机制中的作用。
Osteoarthritis Cartilage. 2014 Jul;22(7):896-903. doi: 10.1016/j.joca.2014.04.026. Epub 2014 May 2.
6
Small Leucine-Rich Proteoglycans (SLRPs) in the Retina.小富含亮氨酸的蛋白聚糖(SLRPs)在视网膜中的作用。
Int J Mol Sci. 2021 Jul 7;22(14):7293. doi: 10.3390/ijms22147293.
7
The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly.小富含亮氨酸的蛋白聚糖在细胞外基质组装中的调控作用。
FEBS J. 2013 May;280(10):2120-37. doi: 10.1111/febs.12136. Epub 2013 Feb 14.
8
Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?富含亮氨酸的小蛋白聚糖和基质金属蛋白酶-14:关键伙伴?
Matrix Biol. 2019 Jan;75-76:271-285. doi: 10.1016/j.matbio.2017.12.006. Epub 2017 Dec 15.
9
Interaction of with extracellular matrix components resulting in immunomodulation and bacterial eradication.与细胞外基质成分相互作用,导致免疫调节和细菌清除。
Matrix Biol Plus. 2020 Jan 13;6-7:100020. doi: 10.1016/j.mbplus.2020.100020. eCollection 2020 May.
10
The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis.富含亮氨酸的小分子重复序列蛋白聚糖在组织修复和动脉粥样硬化中的作用
J Intern Med. 2015 Nov;278(5):447-61. doi: 10.1111/joim.12400.

引用本文的文献

1
Urinary Protein-Biomarkers Reliably Indicate Very Early Kidney Damage in Children With Alport Syndrome Independently of Albuminuria and Inflammation.尿蛋白生物标志物可可靠地指示Alport综合征患儿的极早期肾损伤,且与蛋白尿和炎症无关。
Kidney Int Rep. 2023 Sep 29;8(12):2778-2793. doi: 10.1016/j.ekir.2023.09.028. eCollection 2023 Dec.
2
Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis.骨粘连蛋白:一种调节纤维化和肿瘤发生的细胞外基质因子。
Biomolecules. 2022 Nov 11;12(11):1674. doi: 10.3390/biom12111674.
3
Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury.聚糖蛋白聚糖是一种新型的盐皮质激素受体靶标,参与醛固酮/盐诱导的肾小球损伤。
Int J Mol Sci. 2022 Jun 15;23(12):6680. doi: 10.3390/ijms23126680.
4
Proteoglycans in Toll-like receptor responses and innate immunity.糖胺聚糖在 Toll 样受体反应和固有免疫中的作用。
Am J Physiol Cell Physiol. 2022 Jul 1;323(1):C202-C214. doi: 10.1152/ajpcell.00088.2022. Epub 2022 Jun 8.
5
Osteomodulin positively regulates osteogenesis through interaction with BMP2.骨钙素通过与 BMP2 的相互作用正向调节成骨作用。
Cell Death Dis. 2021 Feb 1;12(2):147. doi: 10.1038/s41419-021-03404-5.
6
DAMPs in Unilateral Ureteral Obstruction.DAMPs 在单侧输尿管梗阻中的作用。
Front Immunol. 2020 Oct 7;11:581300. doi: 10.3389/fimmu.2020.581300. eCollection 2020.

本文引用的文献

1
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease.甜蜜而被低估:心脏疾病中的蛋白聚糖和细胞外基质重塑。
Matrix Biol. 2019 Jan;75-76:286-299. doi: 10.1016/j.matbio.2018.01.001. Epub 2018 Jan 12.
2
Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin.小富含亮氨酸的蛋白聚糖在肾脏炎症中的作用:一把双刃剑。
J Histochem Cytochem. 2018 Apr;66(4):261-272. doi: 10.1369/0022155417738752. Epub 2018 Jan 1.
3
Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.基质的病理生物学——蛋白聚糖和肝素酶在健康和疾病中的核心作用。
FEBS J. 2017 Jan;284(1):7-9. doi: 10.1111/febs.13945.
4
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.蛋白聚糖的新功能:癌症生物学中炎症和自噬的调节
FEBS J. 2017 Jan;284(1):10-26. doi: 10.1111/febs.13963. Epub 2016 Dec 7.
5
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.可溶性双糖链蛋白聚糖的一种新生物学功能:诱导促红细胞生成素产生及红细胞增多症。
Glycoconj J. 2017 Jun;34(3):393-404. doi: 10.1007/s10719-016-9722-y. Epub 2016 Sep 6.
6
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.饰胶蛋白聚糖是一种自噬诱导性蛋白聚糖,是体内正常自噬所必需的。
Matrix Biol. 2015 Oct;48:14-25. doi: 10.1016/j.matbio.2015.09.001. Epub 2015 Sep 4.
7
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.蛋白聚糖的形式与功能:蛋白聚糖的综合命名法。
Matrix Biol. 2015 Mar;42:11-55. doi: 10.1016/j.matbio.2015.02.003. Epub 2015 Feb 18.
8
Lumican: a new inhibitor of matrix metalloproteinase-14 activity.赖氨酰聚糖酶:基质金属蛋白酶-14 活性的一种新抑制剂。
FEBS Lett. 2014 Nov 28;588(23):4319-24. doi: 10.1016/j.febslet.2014.09.040. Epub 2014 Oct 7.
9
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.除了组织损伤相关的分子模式、 toll 样受体和炎性小体之外,它们还能驱动再生和纤维化。
J Am Soc Nephrol. 2014 Jul;25(7):1387-400. doi: 10.1681/ASN.2014010117. Epub 2014 Apr 24.
10
Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology.富含亮氨酸的小分子蛋白聚糖在肾脏和肺部病理生理学中的关键作用。
Biochim Biophys Acta. 2014 Aug;1840(8):2460-70. doi: 10.1016/j.bbagen.2014.01.035. Epub 2014 Feb 5.

富含亮氨酸的小分子蛋白聚糖在宿主免疫和肾脏疾病中的作用

Small leucine rich proteoglycans in host immunity and renal diseases.

作者信息

Zou Wei, Wan Junhui, Li Min, Xing Juanjuan, Chen Qi, Zhang Zhi, Gong Yi

机构信息

Department of Infectious Diseases, The 1st Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.

Department of Gynecology and Obstetrics, The 1st Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

出版信息

J Cell Commun Signal. 2019 Dec;13(4):463-471. doi: 10.1007/s12079-018-0489-8. Epub 2018 Oct 25.

DOI:10.1007/s12079-018-0489-8
PMID:30357553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6946788/
Abstract

The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.

摘要

富含亮氨酸的小分子蛋白聚糖(SLRPs)在结构上由蛋白核心和各种糖胺聚糖侧链组成,根据共同的结构和功能特性分为五类。除了作为细胞外基质(ECM)的重要结构成分外,SLRPs还参与了信号转导和宿主免疫反应的复杂网络。本综述的重点是宿主免疫中的SLRPs。由于宿主免疫在肾脏疾病的发病机制中起重要作用,因此也将讨论SLRPs在这类疾病中的作用。