Módena Sérgio Ferreira, Caldeira Eduardo José, Peres Marco Antonio O, Andreollo Nelson Adami
Department of Surgery, Faculty of Medicine of Jundiaí, Jundiaí; SP, Brazil.
Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, Jundiaí; SP, Brazil.
Arq Bras Cir Dig. 2016 Nov-Dec;29(4):218-222. doi: 10.1590/0102-6720201600040002.
New findings point out that the mechanism of formation of the hernias can be related to the collagenous tissues, under activity of aggressive agents such as the tobacco, alcohol and diabetes.
To analyze the collagen present in the cremaster muscle in patients with inguinal hernias, focusing the effect of tobacco, alcohol, and diabetes.
Fifteen patients with inguinal hernia divided in three groups were studied: group I (n=5) was control; group II (n=5) were smokers and/or drinkers; and group III (n=5) had diabetes mellitus. All subjects were underwent to surgical repair of the inguinal hernias obeying the same pre, intra and postoperative conditions. During surgery, samples of the cremaster muscle were collected for analysis in polarized light microscopy, collagen morphometry and protein.
The area occupied by the connective tissue was higher in groups II and III (p<0.05). The collagen tissue occupied the majority of the samples analyzed in comparison to the area occupied by muscle cells. The content of total protein was higher in groups II and III compared to the control group (p<0.05).
The tobacco, alcohol and diabetes cause a remodel the cremaster muscle, leading to a loss of support or structural change in this region, which may enhance the occurrences and damage related to inguinal hernias.
新的研究结果指出，在烟草、酒精和糖尿病等侵袭性因素的作用下，疝气的形成机制可能与胶原组织有关。
分析腹股沟疝患者提睾肌中的胶原蛋白，重点关注烟草、酒精和糖尿病的影响。
对15例腹股沟疝患者进行分组研究：第一组（n = 5）为对照组；第二组（n = 5）为吸烟者和/或饮酒者；第三组（n = 5）患有糖尿病。所有受试者均在相同的术前、术中和术后条件下接受腹股沟疝手术修复。手术过程中，采集提睾肌样本，用于偏光显微镜分析、胶原形态测量和蛋白质分析。
第二组和第三组结缔组织所占面积更高（p < 0.05）。与肌肉细胞所占面积相比，胶原组织在分析的大多数样本中占主导地位。与对照组相比，第二组和第三组的总蛋白含量更高（p < 0.05）。
烟草、酒精和糖尿病会导致提睾肌重塑，导致该区域失去支撑或结构改变，这可能会增加腹股沟疝的发生及相关损害。
