Silva Marilda Guimarães, Borba Eduardo Ferreira, Mello Suzana Beatriz Veríssimo de, Shinjo Samuel Katsuyuki
Faculdade de Medicina da Universidade de São Paulo, Clínica Médica, Reumatologia, São Paulo/SP, Brazil.
Clinics (Sao Paulo). 2016 Dec 1;71(12):709-714. doi: 10.6061/clinics/2016(12)06.
: To analyse the frequency of metabolic syndrome in young adult female dermatomyositis patients and its possible association with clinical and laboratory dermatomyositis-related features and serum adipocytokines.
: This cross-sectional study included 35 dermatomyositis patients and 48 healthy controls. Metabolic syndrome was defined according to the 2009 Joint Interim Statement.
: Patient age was comparable in the dermatomyositis and control groups, and the median disease duration was 1.0 year. An increased prevalence of metabolic syndrome was detected in the dermatomyositis group (34.3% vs. 6.3%; p=0.001). In addition, increased serum adiponectin and resistin levels were noted in contrast to lower leptin levels. In dermatomyositis patients, adipocytokine levels were correlated with the levels of total cholesterol, low-density cholesterol, triglycerides and muscle enzymes. A comparison of dermatomyositis patients with (n=12) and without (n=23) syndrome metabolic revealed that adipocytokine levels were also correlated with age, and that dermatomyositis patients with metabolic syndrome tended to have more disease activity despite similar adipocytokine levels.
: Metabolic syndrome is highly prevalent in young adult female dermatomyositis patients and is related to age and disease activity. Moreover, increased serum adiponectin and resistin levels were detected in dermatomyositis patients, but lower serum leptin levels were observed.
分析年轻成年女性皮肌炎患者代谢综合征的发生率及其与皮肌炎相关临床和实验室特征以及血清脂肪细胞因子的可能关联。
这项横断面研究纳入了35例皮肌炎患者和48例健康对照。代谢综合征根据2009年联合临时声明进行定义。
皮肌炎组和对照组患者年龄相当，疾病中位病程为1.0年。皮肌炎组代谢综合征患病率升高（34.3%对6.3%；p=0.001）。此外，血清脂联素和抵抗素水平升高，而瘦素水平降低。在皮肌炎患者中，脂肪细胞因子水平与总胆固醇、低密度胆固醇、甘油三酯和肌肉酶水平相关。对有（n=12）和无（n=23）代谢综合征的皮肌炎患者进行比较发现，脂肪细胞因子水平也与年龄相关，并且尽管脂肪细胞因子水平相似，但有代谢综合征的皮肌炎患者往往疾病活动度更高。
代谢综合征在年轻成年女性皮肌炎患者中高度流行，且与年龄和疾病活动度相关。此外，在皮肌炎患者中检测到血清脂联素和抵抗素水平升高，但血清瘦素水平降低。
