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一项针对特定服务中垂直HIV传播的五年回顾:横断面研究。

A five-year review of vertical HIV transmission in a specialized service: cross-sectional study.

作者信息

Hoffmann Izabel Cristina, Santos Wendel Mombaque Dos, Padoin Stela Maris de Mello, Barros Sonia Maria Oliveira de

机构信息

PhD. Nurse, University Hospital, Universidade Federal de Santa Maria (UFSM), Santa Maria (RS) Brazil.

MSc. Nurse, University Hospital, Universidade Federal de Santa Maria (UFSM), Santa Maria (RS), Brazil.

出版信息

Sao Paulo Med J. 2016 Nov-Dec;134(6):508-512. doi: 10.1590/1516-3180.2016.0139140616. Epub 2016 Nov 10.

Abstract

CONTEXT AND OBJECTIVE

: Healthcare professionals need to instill the process of prevention, control and treatment of people infected with HIV into care practice. Through maintaining preventive treatment among HIV-infected pregnant women, it has been demonstrated that prophylactic antiretroviral therapy, scheduled cesarean section and the prohibition of breastfeeding significantly reduce vertical HIV transmission. This study aimed to assess the rates of vertical HIV transmission in a specialized service and identify the factors associated with it.

DESIGN AND SETTING

: Cross-sectional study developed at the University Hospital of Santa Maria (RS), Brazil.

METHODS

: A cross-sectional study was conducted on a sample of 198 notification forms and medical records of HIV-positive pregnant women and exposed children.

RESULTS

: The vertical transmission rate was 2.4%, and three children had been infected by vertical HIV transmission. The statistically significant risk factor was the use of injectable drugs. Delayed reporting of pregnancy, absence of antiretroviral therapy during pregnancy, lack of proper prenatal care, incapacity to perform viral load detection tests and CD4+ T cell counts and obstetric and maternal clinical complications were reported.

CONCLUSIONS

: The vertical transmission rate was high and the recommended intervention measures were not adopted in full. Adequate prophylactic measures need to be implemented in HIV-positive pregnant women prenatally and during the antenatal, delivery and postpartum periods.

摘要

背景与目的

医疗保健专业人员需要将艾滋病毒感染者的预防、控制和治疗过程融入护理实践。通过对感染艾滋病毒的孕妇维持预防性治疗,已证明预防性抗逆转录病毒疗法、择期剖宫产和禁止母乳喂养可显著降低艾滋病毒垂直传播。本研究旨在评估一家专业机构中的艾滋病毒垂直传播率,并确定与之相关的因素。

设计与地点

在巴西圣玛丽亚大学医院(南里奥格兰德州)开展的横断面研究。

方法

对198份艾滋病毒阳性孕妇及受感染儿童的报告表和病历样本进行横断面研究。

结果

垂直传播率为2.4%,有3名儿童通过艾滋病毒垂直传播感染。具有统计学意义的风险因素是使用注射毒品。报告了妊娠报告延迟、孕期未接受抗逆转录病毒治疗、缺乏适当的产前护理、无法进行病毒载量检测和CD4+T细胞计数以及产科和孕产妇临床并发症。

结论

垂直传播率较高,且未充分采取推荐的干预措施。需要对艾滋病毒阳性孕妇在产前、产时和产后实施充分的预防措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73bf/11448727/ffd0ce52a5a5/1806-9460-spmj-134-06-508-gf1.jpg

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