Mubarik Ateeq, Tohid Hassaan
Sindh Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Center for Mind & Brain, University of California, Davis, USA.
Trends Psychiatry Psychother. 2016 Oct-Dec;38(4):198-206. doi: 10.1590/2237-6089-2015-0088.
: To highlight the changes in the frontal lobe of the human brain in people with schizophrenia.
: This was a qualitative review of the literature.
: Many schizophrenic patients exhibit functional, structural, and metabolic abnormalities in the frontal lobe. Some patients have few or no alterations, while some have more functional and structural changes than others. Magnetic resonance imaging (MRI) shows structural and functional changes in volume, gray matter, white matter, and functional activity in the frontal lobe, but the mechanisms underlying these changes are not yet fully understood.
: When schizophrenia is studied as an essential topic in the field of neuropsychiatry, neuroscientists find that the frontal lobe is the most commonly involved area of the human brain. A clear picture of how this lobe is affected in schizophrenia is still lacking. We therefore recommend that further research be conducted to improve understanding of the pathophysiology of this psychiatric dilemma.
突出精神分裂症患者大脑额叶的变化。
这是一项文献的定性综述。
许多精神分裂症患者在额叶表现出功能、结构和代谢异常。一些患者几乎没有或没有改变，而一些患者比其他患者有更多的功能和结构变化。磁共振成像（MRI）显示额叶在体积、灰质、白质和功能活动方面的结构和功能变化，但这些变化背后的机制尚未完全了解。
当精神分裂症作为神经精神病学领域的一个重要课题进行研究时，神经科学家发现额叶是人类大脑中最常受累的区域。目前仍缺乏对精神分裂症中该脑叶如何受到影响的清晰认识。因此，我们建议进行进一步研究，以增进对这一精神疾病困境病理生理学的理解。
