Williamson P
Psychiatric Inpatient Services, Sunnybrook Medical Centre, Toronto, Ontario.
Can J Psychiatry. 1987 Jun;32(5):399-404. doi: 10.1177/070674378703200516.
This paper reviews the possible role of frontal lobe dysfunction in the pathophysiology of schizophrenia. Pathological, computerized axial tomography (CAT) scan and magnetic resonance imaging (MRI) studies have indicated that a substantial number of schizophrenic patients show structural abnormalities in the frontal lobe areas and other parts of the brain. In some cases, these changes can be correlated with negative symptoms. Attempts to study frontal lobe function with neuropsychological tests, topographic EEG, cerebral blood flow (CBF) and positron emission tomography (PET) scans have also indicated that a substantial number of schizophrenics show abnormalities compared to normal controls. However, these abnormalities can be seen to some degree in other conditions. As well, patients early in the course of their illness tend not to show frontal lobe functional abnormalities. The implications of these findings for current theories of schizophrenia are discussed.
本文综述了额叶功能障碍在精神分裂症病理生理学中可能发挥的作用。病理学、计算机断层扫描（CAT）和磁共振成像（MRI）研究表明，相当数量的精神分裂症患者额叶区域及大脑其他部位存在结构异常。在某些情况下，这些变化与阴性症状相关。通过神经心理学测试、脑电地形图、脑血流量（CBF）和正电子发射断层扫描（PET）来研究额叶功能的尝试也表明，与正常对照组相比，相当数量的精神分裂症患者存在异常。然而，这些异常在其他情况下也会在一定程度上出现。此外，病程早期的患者往往不会表现出额叶功能异常。本文还讨论了这些发现对当前精神分裂症理论的意义。
