Cusano Ellen L, Ali Raafi, Sawyer Michael B, Chambers Carole R, Tang Patricia A
1 Faculty of Medicine, University of Ottawa, ON, Canada.
2 Cross Cancer Institute and University of Alberta, Edmonton, AB, Canada.
J Oncol Pharm Pract. 2018 Apr;24(3):163-169. doi: 10.1177/1078155216687153. Epub 2017 Jan 11.
Purpose Elastomeric pumps are used to administer 46-hour infusions of 5-fluorouracil (5FU). Baxter suggests patients visually monitor their pumps to ensure that infusions are proceeding correctly. This can be confusing and lead to concerns about under- or over-dosing. Baxter has not considered weighing pumps as a validated method for monitoring. This study aims to validate weighing as a more accurate method for patients and healthcare professionals, and describe real life Baxter Infusor™ variability. Methods Patients who had been started on a 46-hour 5FU infusion returned to the clinic approximately 24 h after starting treatment. The pump was weighed on a StarFrit kitchen scale, and date, time, and weights recorded. Patients were asked if they had a preference for weighing or visually inspecting their pump. Results Pumps ( n = 103) were weighed between 17.25 and 27.5 h after connection. The average weight of a pump was 189 g. Of 103 pumps weighed, 99 weighed less than expected, corresponding to average flow rates of 5.69 mL/h over the elapsed time. The expected flow rate is 5 mL/h with 10% variability. Average flow rates within the 17.25- to 27.5-hour window were 4.561 mL/h, which is 8.78% slower than expected, but within the 10% known variability. Forty-seven percent of patients didn't have a preference for either method, but for those who did have a preference, more than twice as many preferred weighing. Conclusion With proper education, weighing Baxter Infusors at home with kitchen scales can be an accepted and objective alternative to the current recommendation of visual inspection.
目的 弹性泵用于进行46小时的5-氟尿嘧啶（5FU）输注。百特公司建议患者目视监测其泵，以确保输注过程正确。这可能会造成混淆，并引发对剂量不足或过量的担忧。百特公司尚未将称量泵作为一种经过验证的监测方法。本研究旨在验证称量作为一种对患者和医护人员而言更准确的方法，并描述实际使用中的百特输液器™的变异性。方法 开始进行46小时5FU输注的患者在开始治疗后约24小时返回诊所。使用StarFrit厨房秤称量泵，并记录日期、时间和重量。询问患者他们更喜欢称量还是目视检查他们的泵。结果 在连接后17.25至27.5小时之间称量了泵（n = 103）。一个泵的平均重量为189克。在称量的103个泵中，99个的重量低于预期，对应于在经过的时间内平均流速为5.69毫升/小时。预期流速为5毫升/小时，变异性为10%。在17.25至27.5小时窗口内的平均流速为4.561毫升/小时，比预期慢8.78%，但在已知的10%变异性范围内。47%的患者对两种方法都没有偏好，但对于那些有偏好的患者，更喜欢称量的人数是更喜欢目视检查的人数的两倍多。结论 通过适当的教育，在家中使用厨房秤称量百特输液器可以成为当前目视检查建议的一种可接受且客观的替代方法。
