van Tienhoven-Wind Lynnda J N, Dullaart Robin P F
Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Lipids Health Dis. 2017 Jan 11;16(1):6. doi: 10.1186/s12944-016-0403-4.
Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown.
Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T levels within the institutional reference range).
Neither plasma leptin nor adiponectin was significantly correlated with TSH or free T in subjects with and without MetS. In the whole group, high sensitivity C-reactive protein (hs-CRP) was positively correlated with the L/A ratio (r = 0.485, P < 0.001). Notably, the L/A ratio was positively correlated with TSH in subjects with MetS (r = 0.252, P = 0.040) but not in subjects without MetS (r = -0.068, P = 0.54; interaction term, P = 0.027). In MetS subjects, the L/A ratio remained positively related with TSH after adjustment for age, sex, diabetes status, hs-CRP and the use of antihypertensive and glucose lowering medication (β = 0.283, P = 0.018), as well as after adjustment for individual MetS components (β = 0.294, P = 0.020).
In the context of MetS, a higher TSH within the euthyroid range confers an increased L/A ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.
甲状腺功能正常范围内甲状腺功能略低可能会增加动脉粥样硬化易感性。瘦素/脂联素（L/A）比值与心血管疾病相关，反映脂肪组织功能障碍。L/A比值与甲状腺功能略低之间的关系尚不清楚。
记录了67例患有代谢综合征（Mets）的空腹受试者和86例无Mets的甲状腺功能正常受试者（促甲状腺激素（TSH）和游离甲状腺素（游离T）水平在机构参考范围内）中，甲状腺刺激激素（TSH）和游离甲状腺素（游离T）与瘦素、脂联素及L/A比值之间的关系。
在有和无Mets的受试者中，血浆瘦素和脂联素均与TSH或游离T无显著相关性。在整个研究组中，高敏C反应蛋白（hs-CRP）与L/A比值呈正相关（r = 0.485，P < 0.001）。值得注意的是，在患有Mets的受试者中，L/A比值与TSH呈正相关（r = 0.252，P = 0.040），而在无Mets的受试者中则无相关性（r = -0.068，P = 0.54；交互项，P = 0.027）。在患有Mets的受试者中，在调整年龄、性别、糖尿病状态、hs-CRP以及使用抗高血压和降糖药物后，L/A比值仍与TSH呈正相关（β = 0.283，P = 0.018），在调整个体Mets组分后也是如此（β = 0.294，P = 0.020）。
在Mets背景下，甲状腺功能正常范围内较高的TSH会导致L/A比值升高，L/A比值是动脉粥样硬化易感性和脂肪细胞功能障碍的一个指标。
