在甲状腺功能正常的个体中，血清对氧磷酶-1 活性与游离甲状腺素呈负相关：PREVEND 队列研究。

Serum paraoxonase-1 activity is inversely related to free thyroxine in euthyroid subjects: The PREVEND Cohort Study.

机构信息

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

出版信息

Eur J Clin Invest. 2018 Jan;48(1). doi: 10.1111/eci.12860. Epub 2017 Dec 7.

DOI:10.1111/eci.12860

PMID:29171874

Abstract

BACKGROUND

Low-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with thyroid stimulating hormone (TSH), free T , free T , lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS).

MATERIALS AND METHODS

Serum PON-1 activity (arylesterase activity), TSH, free T , free T , lipids and apoA-I was measured in 2206 euthyroid subjects (aged 28-75 years; 1138 men (age 49 ± 13 years) and 1068 women (age 46 ± 12 years), recruited from the general population (PREVEND cohort).

RESULTS

In age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (β = -0.045, P = .036) and inversely to free T (β = -0.042, P = .050) but not to free T (β = -0.027, P = .20). PON-1 activity was positively related to total cholesterol, non-HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA-I (P < .01 to <.001). The inverse relationship of PON-1 activity with free T remained present after adjustment for lipids and other potential confounders (β = -0.066, P = .002), but the positive relationship with TSH lost significance (β = 0.034, P = .11). The inverse relationship of PON-1 activity with free T was not different in subjects with vs without MetS (P = .94), nor modified by the presence of its individual components (P ≥ .22 for each).

CONCLUSIONS

Serum PON-1 activity is inversely associated with free T in euthyroid subjects, suggesting that low-normal thyroid function may affect PON-1 regulation.

摘要

背景

甲状腺功能正常范围内的低甲状腺功能被认为可增加动脉粥样硬化易感性。对氧磷酶-1（PON-1）通过减轻氧化应激可能有助于预防动脉粥样硬化性心血管疾病的发展。我们评估了 PON-1 与甲状腺刺激激素（TSH）、游离 T 、游离 T 、脂质和载脂蛋白（apo）A-I 在甲状腺功能正常个体中的关系，并评估了这些关系在代谢综合征（MetS）背景下是否会发生变化。

材料和方法

在 2206 例甲状腺功能正常的受试者（年龄 28-75 岁；1138 名男性（年龄 49±13 岁）和 1068 名女性（年龄 46±12 岁））中测量了血清 PON-1 活性（芳基酯酶活性）、TSH、游离 T 、游离 T 、脂质和 apoA-I。这些受试者来自普通人群（PREVEND 队列）。

结果

在年龄和性别调整分析中，PON-1 活性（分为三分位）与 TSH 呈负相关（β=-0.045，P=0.036），与游离 T 呈正相关（β=-0.042，P=0.050），但与游离 T 无相关性（β=-0.027，P=0.20）。PON-1 活性与总胆固醇、非高密度脂蛋白胆固醇和甘油三酯呈正相关，与高密度脂蛋白胆固醇和 apoA-I 呈正相关（P<.01 至<.001）。调整脂质和其他潜在混杂因素后，PON-1 活性与游离 T 的负相关仍然存在（β=-0.066，P=0.002），但与 TSH 的正相关失去了意义（β=0.034，P=0.11）。PON-1 活性与游离 T 的负相关在有或没有 MetS 的受试者中没有差异（P=0.94），其单个成分的存在也没有改变（P≥0.22）。