APP Modulates Aβ-Induced Activation of Microglia in Mouse Model of Alzheimer's Disease.
作者信息
Datta Dibyadeep
机构信息
Department of Neuroscience, Yale University, New Haven, Connecticut 06510
出版信息
J Neurosci. 2017 Jan 11;37(2):238-240. doi: 10.1523/JNEUROSCI.3122-16.2017.
Abstract
摘要
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The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.阿杜卡努单抗可减少阿尔茨海默病中的 Aβ 斑块。
Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323.
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APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease.APP在阿尔茨海默病小鼠模型中调节小胶质细胞表型。
J Neurosci. 2016 Aug 10;36(32):8471-86. doi: 10.1523/JNEUROSCI.4654-15.2016.
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Complement and microglia mediate early synapse loss in Alzheimer mouse models.补体和小胶质细胞介导阿尔茨海默病小鼠模型中的早期突触丧失。
Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31.
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Immune attack: the role of inflammation in Alzheimer disease.免疫攻击：炎症在阿尔茨海默病中的作用。
Nat Rev Neurosci. 2015 Jun;16(6):358-72. doi: 10.1038/nrn3880.
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Microglia: new roles for the synaptic stripper.小胶质细胞：突触清除器的新角色。
Neuron. 2013 Jan 9;77(1):10-8. doi: 10.1016/j.neuron.2012.12.023.
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Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.阿尔茨海默病中的炎症——基础科学和临床文献简述。
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006346. doi: 10.1101/cshperspect.a006346.
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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.静息态小胶质细胞在体内直接监测突触的功能状态，并决定缺血性终末的命运。
J Neurosci. 2009 Apr 1;29(13):3974-80. doi: 10.1523/JNEUROSCI.4363-08.2009.
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Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.阿尔茨海默病中的小胶质细胞、淀粉样蛋白与认知：一项[11C]（R）PK11195-PET和[11C]PIB-PET研究。
Neurobiol Dis. 2008 Dec;32(3):412-9. doi: 10.1016/j.nbd.2008.08.001. Epub 2008 Aug 15.
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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.小胶质细胞与淀粉样蛋白相互作用的动力学表明其在斑块维持中发挥作用。
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