Pasquinelli P, Vaglini F, Pieracci D, Ettorre V, Puccini M, Malvaldi G
Institute of General Pathology, University of Pisa, Italy.
Int J Tissue React. 1989;11(1):15-20.
Thiobenzamide (TB) is a thiono-containing compound endowed with liver-damaging properties and promoting ability on liver carcinogenesis. When administered in a single dose to normal as well as to adrenalectomized rats, this compound induced a striking thymus cortex involution without relevant effects on the morphological features of other lymphoid organs such as spleen and lymph nodes. The proximal TB metabolite TB-S-oxide (TBSO) shared these effects with the parent compound, whereas the terminal metabolite benzamide (BA) was ineffective. The effect of TB on thymus was found to be dose- and age-dependent. Furthermore, acute TB treatment 12h before priming with the T-dependent antigen sheep erythrocytes impaired the secondary antibody response. In addition, TB administration affected not only cell-mediated immunity (as evidenced by a decreased delayed hypersensitivity response) but also mitogen-induced proliferation of blood lymphocytes. On the contrary, the chemotactic response of polymorphonuclear leukocytes obtained from TB-treated rats was unchanged.
硫代苯甲酰胺（TB）是一种含硫代羰基的化合物，具有肝损伤特性，并能促进肝癌发生。当以单剂量给予正常大鼠和肾上腺切除大鼠时，该化合物可引起明显的胸腺皮质萎缩，而对脾脏和淋巴结等其他淋巴器官的形态特征无相关影响。TB的近端代谢产物TB-S-氧化物（TBSO）与母体化合物具有相同的作用，而末端代谢产物苯甲酰胺（BA）则无效。发现TB对胸腺的作用具有剂量和年龄依赖性。此外，在用T细胞依赖性抗原绵羊红细胞致敏前12小时进行急性TB处理会损害二次抗体反应。此外，给予TB不仅影响细胞介导的免疫（如迟发型超敏反应降低所证明），还影响丝裂原诱导的血液淋巴细胞增殖。相反，从TB处理的大鼠获得的多形核白细胞的趋化反应未改变。
