Pasquinelli P, Bruschi F, Saviozzi M, Malvaldi G
Boll Soc Ital Biol Sper. 1985 Jan 30;61(1):61-6.
Thiobenzamide (TB) administration to rats (1 g/Kg of diet for 4 weeks) 10 days after a single i.p. injection of dimethylnitrosamine promotes the growth of preneoplastic liver lesions as evidenced by the sharp increase in number and area of gamma-glutamyltranspeptidase-positive hepatocellular foci. At the same time the number of the plaque forming cells isolated from the spleen of rats challenged with sheep red blood cell after the completion of a TB cycle is significantly lower than in the controls 5 as well 13 days after immunization. Accordingly, TB could act as immunodepressant in the rat; this should be taken into account as far as the promoting ability of such xenobiotic is concerned.
在大鼠单次腹腔注射二甲基亚硝胺10天后，给予其硫代苯甲酰胺（TB）（1克/千克饮食，持续4周），可促进癌前肝损伤的生长，这可通过γ-谷氨酰转肽酶阳性肝细胞灶数量和面积的急剧增加得到证明。同时，在TB给药周期结束后，用绵羊红细胞攻击的大鼠脾脏中分离出的空斑形成细胞数量在免疫后5天和13天均显著低于对照组。因此，TB在大鼠中可能作为免疫抑制剂起作用；就这种外源性物质的促进能力而言，应考虑到这一点。
