Ai Fanrong, Goel Shreya, Zhan Yonghua, Valdovinos Hector F, Chen Feng, Barnhart Todd E, Cai Weibo
School of Mechanical & Electrical Engineering, Nanchang UniversityJiangxi, China; Department of Radiology, University of Wisconsin-MadisonMadison, WI.
Materials Science Program, University of Wisconsin-Madison Madison, WI.
Am J Transl Res. 2016 Dec 15;8(12):5591-5600. eCollection 2016.
Radioluminescence imaging (RLI) employs high energy particles from radioisotope decay for excitation of selected nanophosphors. Co-injection of radiopharmaceuticals and nanophosphors suffers from suboptimal RL efficiency owing to the large separation between the source and the emitter. In addition, vastly different pharmacokinetic profiles of the two further impede the practical applications of this approach. To overcome the above challenges, chelator-free radiolabeled nanophosphors with excellent RL efficiency and dual-modality imaging capabilities have been proposed. Abundant O donors on GdOS:Eu could intrinsically chelate oxophilic radionuclide Zr with ~80 % labeling yield. Positron emission tomography demonstrated superb long-term radiostability of [Zr]GdOS:Eu@PEG nanoparticles , and a conventional optical imaging system was used to study radiouminescence properties of [Zr]GdOS:Eu@PEG nanoparticles and .
放射发光成像（RLI）利用放射性同位素衰变产生的高能粒子来激发选定的纳米磷光体。由于源与发射体之间距离较大，放射性药物与纳米磷光体的共注射存在放射发光效率欠佳的问题。此外，两者截然不同的药代动力学特征进一步阻碍了该方法的实际应用。为克服上述挑战，已提出具有优异放射发光效率和双模态成像能力的无螯合剂放射性标记纳米磷光体。GdOS:Eu上丰富的氧供体可固有地螯合亲氧放射性核素Zr，标记产率约为80%。正电子发射断层扫描显示[Zr]GdOS:Eu@PEG纳米颗粒具有出色的长期放射性稳定性，并使用传统光学成像系统研究[Zr]GdOS:Eu@PEG纳米颗粒的放射发光特性。
