The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou 350116, P. R. China.
Nanoscale. 2017 Jan 7;9(1):56-61. doi: 10.1039/c6nr08281e. Epub 2016 Dec 1.
Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of GdOS around GNRs is reported to address these limitations of GNRs. After the coating of the GdOS shell, the as-fabricated GdOS coated GNRs (GNRs@GdOS) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance. The strong absorption in the near-infrared region renders GNRs@GdOS outstanding photoacoustic imaging and photothermal therapy capabilities. Moreover, owing to the T shortening ability of GdOS, the GNRs@GdOS also show an excellent T MRI contrast performance. The GNRs@GdOS thus can serve as a versatile nanoplatform for cancer theranostics combining dual-modal imaging and photothermal therapy.
金纳米棒（GNRs）由于其独特的光学性质，正在成为癌症治疗学中一种很有前途的纳米平台。然而，它们仍然存在许多限制，例如高细胞毒性、低热力学和生物稳定性，以及将其他成像模式集成的繁琐过程，这限制了它们在进一步的实际生物医学应用中的发展。在这项工作中，报道了一种通过一步在 GNRs 周围包覆 GdOS 的策略来解决 GNRs 的这些限制。包覆 GdOS 壳后，所制备的 GdOS 包覆金纳米棒（GNRs@GdOS）表现出增强的生物相容性和光稳定性，以及可调谐的局域表面等离子体共振。在近红外区域的强吸收使 GNRs@GdOS 具有出色的光声成像和光热治疗能力。此外，由于 GdOS 的 T1 缩短能力，GNRs@GdOS 还表现出优异的 T1 磁共振成像对比性能。因此，GNRs@GdOS 可以作为一种多功能纳米平台，用于结合双模式成像和光热治疗的癌症治疗学。
