质子泵抑制剂所致低镁血症和低钙血症：病例回顾
Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review.
作者信息
Sivakumar Jonathan
机构信息
Discipline of Medicine, The University of Adelaide, Royal Adelaide Hospital Adelaide, South Australia 5000, Australia.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2016 Dec 25;8(4):169-174. eCollection 2016.
Abstract
Proton pump inhibitor (PPI)-induced hypomagnesaemia is a rare but serious adverse effect of a widely prescribed medication. It has become an increasingly recognised complication since 2006, with the U.S. Food and Drug Administration issuing a warning for this risk with regards to long-term PPI use. We present the case of PPI-associated hypomagnesaemia and hypocalcaemia. A 91 year old male presented with tetany from severe hypomagnesaemia and hypocalcaemia. This condition occurred in the context of 18 months of PPI use, and resolved following cessation of PPI therapy and the replenishment of magnesium and calcium stores. Monitoring of magnesium, calcium and potassium levels is crucial in patients prescribed PPIs long-term; especially the elderly patient.
摘要
质子泵抑制剂（PPI）引起的低镁血症是一种广泛使用的药物罕见但严重的不良反应。自2006年以来，它已成为一种越来越被认识到的并发症，美国食品药品监督管理局已就长期使用PPI的这种风险发出警告。我们报告一例与PPI相关的低镁血症和低钙血症病例。一名91岁男性因严重低镁血症和低钙血症出现手足搐搦。这种情况发生在使用PPI 18个月的背景下，在停止PPI治疗并补充镁和钙储备后得到缓解。对于长期服用PPI的患者，尤其是老年患者，监测镁、钙和钾水平至关重要。
相似文献
1
Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review.质子泵抑制剂所致低镁血症和低钙血症：病例回顾
Int J Physiol Pathophysiol Pharmacol. 2016 Dec 25;8(4):169-174. eCollection 2016.
2
Hypomagnesaemia leading to parathyroid dysfunction, hypocalcaemia, and hypokalaemia as a complication of long-term treatment with a proton pump inhibitor - a literature review.长期使用质子泵抑制剂导致低镁血症进而引发甲状旁腺功能障碍、低钙血症和低钾血症：文献综述。
Endokrynol Pol. 2024;75(4):359-365. doi: 10.5603/ep.98576.
3
The Perilous PPI: Proton Pump Inhibitor as a Cause of Clinically Significant Hypomagnesaemia.危险的质子泵抑制剂：质子泵抑制剂作为临床上显著低镁血症的一个病因
J ASEAN Fed Endocr Soc. 2020;35(1):109-113. doi: 10.15605/jafes.035.01.18. Epub 2020 Apr 20.
4
[Severe hypomagnesaemia due to proton pump inhibitor use].[因使用质子泵抑制剂导致的严重低镁血症]
Ned Tijdschr Geneeskd. 2018 Aug 3;162:D2702.
5
Prevalence and outcomes of proton pump inhibitor associated hypomagnesemia in chronic kidney disease.质子泵抑制剂相关低镁血症在慢性肾脏病中的流行情况及转归。
PLoS One. 2018 May 25;13(5):e0197400. doi: 10.1371/journal.pone.0197400. eCollection 2018.
6
A patient on long-term proton pump inhibitors develops sudden seizures and encephalopathy: an unusual presentation of hypomagnesaemia.一名长期服用质子泵抑制剂的患者突发癫痫和脑病：低镁血症的不寻常表现。
Case Rep Gastrointest Med. 2012;2012:632721. doi: 10.1155/2012/632721. Epub 2012 Nov 18.
7
Severe symptomatic hypomagnesaemia induced by the chronic use of proton pump inhibitors: a case report of a patient with Zollinger-Ellison syndrome.长期使用质子泵抑制剂引起的严重症状性低镁血症：一例卓艾综合征患者的病例报告
Acta Clin Belg. 2014 Jan-Feb;69(1):62-5. doi: 10.1179/0001551213Z.0000000008.
8
Hypomagnesaemia associated with long-term use of proton pump inhibitors.与长期使用质子泵抑制剂相关的低镁血症。
Gastroenterol Rep (Oxf). 2015 Aug;3(3):243-53. doi: 10.1093/gastro/gou054. Epub 2014 Aug 19.
9
Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.菊粉可显著改善质子泵抑制剂所致低镁血症患者的血清镁水平。
Aliment Pharmacol Ther. 2016 Jun;43(11):1178-85. doi: 10.1111/apt.13619. Epub 2016 Apr 18.
10
Hypomagnesaemia and hypocalcaemia in a patient with systemic sclerosis: role of proton pump inhibitors.系统性硬化症患者的低镁血症和低钙血症：质子泵抑制剂的作用
Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-225-7. Epub 2014 Jul 28.
引用本文的文献
1
The Eucalcemic Patient With Elevated Parathyroid Hormone Levels.甲状旁腺激素水平升高的血钙正常患者。
J Endocr Soc. 2023 Jan 26;7(4):bvad013. doi: 10.1210/jendso/bvad013. eCollection 2023 Feb 9.
2
Vitamin D deficiency in children with cerebral palsy: A narrative review of epidemiology, contributing factors, clinical consequences and interventions.脑瘫患儿维生素D缺乏症：流行病学、影响因素、临床后果及干预措施的叙述性综述
Saudi J Biol Sci. 2022 Apr;29(4):2007-2013. doi: 10.1016/j.sjbs.2021.12.026. Epub 2021 Dec 16.
3
Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients.与住院COVID-19患者相关的表型和临床风险因素的组合分析
Front Digit Health. 2021 Jul 8;3:660809. doi: 10.3389/fdgth.2021.660809. eCollection 2021.
4
An overview of diagnosis and management of drug-induced hypomagnesemia.药物诱导性低镁血症的诊断与治疗概述。
Pharmacol Res Perspect. 2021 Aug;9(4):e00829. doi: 10.1002/prp2.829.
5
Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review.肝移植患者焦磷酸钙沉积症（CPPD）：是低镁血症、他克莫司还是两者均有责任？基于病例的文献复习。
Rheumatol Int. 2022 Jun;42(6):1105-1112. doi: 10.1007/s00296-021-04828-0. Epub 2021 Mar 11.
6
Prevalence and risk factors of long-term proton pump inhibitors-associated hypomagnesemia: a cross-sectional study in hospitalized patients.质子泵抑制剂相关低镁血症的患病率及危险因素：一项住院患者的横断面研究。
Intern Emerg Med. 2021 Apr;16(3):711-717. doi: 10.1007/s11739-020-02501-1. Epub 2020 Oct 1.
7
Posaconazole and isavuconazole induced hypomagnesaemia.泊沙康唑和艾沙康唑可引起低镁血症。
Med Mycol Case Rep. 2018 Sep 28;23:29-30. doi: 10.1016/j.mmcr.2018.09.007. eCollection 2019 Mar.
8
Magnesium and Human Health: Perspectives and Research Directions.镁与人类健康：观点与研究方向
Int J Endocrinol. 2018 Apr 16;2018:9041694. doi: 10.1155/2018/9041694. eCollection 2018.
本文引用的文献
1
Appropriate proton pump inhibitors use in elderly outpatients according to recommendations.根据建议在老年门诊患者中合理使用质子泵抑制剂。
Geriatr Psychol Neuropsychiatr Vieil. 2016 Dec 1;14(4):383-388. doi: 10.1684/pnv.2016.0623.
2
Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study.成人使用质子泵抑制剂的情况：一项丹麦全国性药物利用研究。
Therap Adv Gastroenterol. 2016 Sep;9(5):671-8. doi: 10.1177/1756283X16650156. Epub 2016 May 26.
3
Sustained effectiveness of a multifaceted intervention to reduce potentially inappropriate prescribing in older patients in primary care (OPTI-SCRIPT study).一项多方面干预措施在初级保健中减少老年患者潜在不适当处方的持续有效性（OPTI-SCRIPT研究）。
Implement Sci. 2016 Jun 2;11(1):79. doi: 10.1186/s13012-016-0442-2.
4
Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms.质子泵抑制剂所致低镁血症：当前研究及提出的机制
World J Nephrol. 2016 Mar 6;5(2):152-7. doi: 10.5527/wjn.v5.i2.152.
5
Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?慢性血液透析患者低镁血症与质子泵抑制剂之间是否存在关系？
Eur J Intern Med. 2016 May;30:99-103. doi: 10.1016/j.ejim.2016.01.026. Epub 2016 Feb 19.
6
Hypocalcemia in Malignancy - Unexpected but Common.
Cureus. 2015 Dec 31;7(12):e442. doi: 10.7759/cureus.442.
7
Magnesium Deficiency and Proton-Pump Inhibitor Use: A Clinical Review.镁缺乏与质子泵抑制剂的使用：一项临床综述
J Clin Pharmacol. 2016 Jun;56(6):660-8. doi: 10.1002/jcph.672. Epub 2015 Dec 30.
8
'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?“柠檬腿”：为何有些患者在使用质子泵抑制剂时会出现严重低镁血症？
Intest Res. 2015 Jul;13(3):227-32. doi: 10.5217/ir.2015.13.3.227. Epub 2015 Jun 9.
9
The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis.质子泵抑制剂的使用与低镁血症风险之间的关联：一项系统评价和荟萃分析。
PLoS One. 2014 Nov 13;9(11):e112558. doi: 10.1371/journal.pone.0112558. eCollection 2014.
10
Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study.质子泵抑制剂与低镁血症导致的住院治疗：一项基于人群的病例对照研究。
PLoS Med. 2014 Sep 30;11(9):e1001736. doi: 10.1371/journal.pmed.1001736. eCollection 2014 Sep.
Zotero 插件