• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid.三例注射长效皮质类固醇后发生过敏反应的病例，有证据表明对聚乙二醇而非活性类固醇存在IgE致敏。
Clin Transl Allergy. 2017 Jan 10;7:2. doi: 10.1186/s13601-016-0138-3. eCollection 2017.
2
IgE-Mediated Anaphylaxis Induced by Macrogol 6000.聚乙二醇6000诱导的IgE介导的过敏反应
J Investig Allergol Clin Immunol. 2016;26(6):398-400. doi: 10.18176/jiaci.0089.
3
Anaphylaxis to intravenous paracetamol containing povidone. A case report and narrative review of excipient allergy related to anaesthesia.对含聚维酮的静脉注射对乙酰氨基酚过敏。一例病例报告及与麻醉相关辅料过敏的叙述性综述。
Anaesth Intensive Care. 2020 Sep;48(5):404-408. doi: 10.1177/0310057X20940318. Epub 2020 Oct 4.
4
Anaphylaxis to beta-lactam antibiotics at pediatric age: Six-year survey.儿童期对β-内酰胺类抗生素的过敏反应：六年调查
Allergol Immunopathol (Madr). 2019 Mar-Apr;47(2):128-132. doi: 10.1016/j.aller.2018.07.008. Epub 2018 Sep 21.
5
Skin testing for immediate hypersensitivity to corticosteroids: a case series and literature review.皮肤测试对皮质类固醇的即刻超敏反应：病例系列和文献复习。
Clin Exp Allergy. 2015 Mar;45(3):669-76. doi: 10.1111/cea.12441.
6
Polyethylene glycol as a cause of anaphylaxis.聚乙二醇作为过敏反应的一个原因。
Allergy Asthma Clin Immunol. 2016 Dec 13;12:67. doi: 10.1186/s13223-016-0172-7. eCollection 2016.
7
Evaluation of the Potential Risk Factors for Drug-Induced Anaphylaxis in Adult Patients.成年患者药物性过敏反应潜在危险因素的评估
Int Arch Allergy Immunol. 2019;178(2):167-176. doi: 10.1159/000494130. Epub 2018 Nov 16.
8
Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy?对碘化造影剂的过敏反应：非过敏性超敏反应还是IgE介导的过敏反应？
AJR Am J Roentgenol. 2008 Mar;190(3):666-70. doi: 10.2214/AJR.07.2872.
9
Anaphylaxis to Excipients in Current Clinical Practice: Evaluation and Management.当前临床实践中辅料的过敏反应：评估与管理。
Immunol Allergy Clin North Am. 2022 May;42(2):239-267. doi: 10.1016/j.iac.2021.12.008. Epub 2022 Mar 31.
10
Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France.对双氯芬酸的过敏反应：法国过敏监测网络报告的 9 例病例。
Allergy. 2014 Oct;69(10):1420-3. doi: 10.1111/all.12458. Epub 2014 Jul 30.

引用本文的文献

1
Fever for days: A challenging case of dalbavancin-induced fever.持续多日发热：一例由达巴万星引起发热的疑难病例
IDCases. 2024 Dec 24;39:e02138. doi: 10.1016/j.idcr.2024.e02138. eCollection 2025.
2
The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review.2019年冠状病毒病大流行对皮肤病的影响：一项新颖的全面综述
Dermatopathology (Basel). 2022 Jun 29;9(3):212-243. doi: 10.3390/dermatopathology9030027.
3
Complications in image-guided musculoskeletal injections.影像引导下肌肉骨骼注射的并发症。
Skeletal Radiol. 2022 Nov;51(11):2097-2104. doi: 10.1007/s00256-022-04076-8. Epub 2022 May 27.
4
Anaphylaxis to Excipients in Current Clinical Practice: Evaluation and Management.当前临床实践中辅料的过敏反应：评估与管理。
Immunol Allergy Clin North Am. 2022 May;42(2):239-267. doi: 10.1016/j.iac.2021.12.008. Epub 2022 Mar 31.
5
Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work-up and decision points for vaccination during the COVID-19 pandemic.患者队列中对聚乙二醇和聚山梨酯的过敏反应：COVID-19大流行期间疫苗接种的诊断检查及决策要点
Clin Transl Allergy. 2022 Jan 8;12(1):e12111. doi: 10.1002/clt2.12111. eCollection 2022 Jan.
6
Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.潜在危险：认识赋形剂作为药物和疫苗过敏反应的潜在原因。
J Allergy Clin Immunol Pract. 2021 Aug;9(8):2968-2982. doi: 10.1016/j.jaip.2021.03.002. Epub 2021 Mar 15.

本文引用的文献

1
Immediate-type hypersensitivity to polyethylene glycols: a review.对聚乙二醇的速发型超敏反应：综述
Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760.
2
Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure.有或无意外再次接触的洗必泰过敏患者中特异性IgE血浆水平的动态变化
Clin Exp Allergy. 2016 Aug;46(8):1090-8. doi: 10.1111/cea.12743. Epub 2016 May 11.
3
Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance.在青霉素过敏患者中，血清特异性IgE阳性的半衰期较短，其转阴并不总是表明耐受。
Clin Transl Allergy. 2014 Oct 29;4:34. doi: 10.1186/2045-7022-4-34. eCollection 2014.
4
Inhibition of polyethylene glycol-induced histamine release by monomeric ethylene and diethylene glycol: a case of probable polyethylene glycol allergy.单体乙二醇和二甘醇对聚乙二醇诱导的组胺释放的抑制作用：一例可能的聚乙二醇过敏病例。
J Allergy Clin Immunol. 2013 May;131(5):1425-7. doi: 10.1016/j.jaci.2012.09.037. Epub 2012 Dec 8.
5
A case of anaphylaxis caused by macrogol 3350 after injection of a corticosteroid.注射皮质类固醇后由聚乙二醇3350引起的过敏反应一例。
Contact Dermatitis. 2012 Dec;67(6):376-8. doi: 10.1111/j.1600-0536.2012.02104.x.
6
Usefulness of oral macrogol challenge in anaphylaxis after intra-articular injection of corticosteroid preparation.关节腔内注射皮质类固醇制剂后发生过敏反应时口服聚乙二醇激发试验的效用
Allergy. 2008 Apr;63(4):478-9. doi: 10.1111/j.1398-9995.2007.01610.x.
7
Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.化妆品中使用的聚乙二醇及其衍生物的安全性评估。
Toxicology. 2005 Oct 15;214(1-2):1-38. doi: 10.1016/j.tox.2005.06.001.
8
Anaphylaxis to macrogol 4000 after a parenteral corticoid injection.注射胃肠外皮质激素后对聚乙二醇4000过敏。
Allergy. 2005 May;60(5):705-6. doi: 10.1111/j.1398-9995.2005.00783.x.

三例注射长效皮质类固醇后发生过敏反应的病例，有证据表明对聚乙二醇而非活性类固醇存在IgE致敏。

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid.

作者信息

Brandt Nicolaj, Garvey Lene H, Bindslev-Jensen Ulla, Kjaer Henrik Fomsgaard, Bindslev-Jensen Carsten, Mortz Charlotte G

机构信息

Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Department of Dermatology and Allergy, Allergy Clinic, Gentofte Hospital, 2900 Hellerup, Denmark.

出版信息

Clin Transl Allergy. 2017 Jan 10;7:2. doi: 10.1186/s13601-016-0138-3. eCollection 2017.

DOI:10.1186/s13601-016-0138-3
PMID:28078080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5223300/
Abstract

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

摘要

我们报告了3例注射长效皮质类固醇后发生过敏反应的病例。起初，怀疑类固醇是引发因素，但经过评估发现辅料聚乙二醇是引发因素。其中1例患者对几种无关药物有反应。需要提高对聚乙二醇等辅料过敏反应的认识，尤其是在活性药物过敏试验为阴性以及有反复对看似无关药物过敏史的患者中。为了做出正确诊断，用可疑药物的确切制剂以及包括辅料在内的所有成分进行检测很重要。