Sahin-Calapoglu Nilufer, Demirci Serpil, Calapoglu Mustafa, Yasar Baris
Department of Medical Biology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
Parkinsons Dis. 2016;2016:5042604. doi: 10.1155/2016/5042604. Epub 2016 Dec 18.
. Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson's disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. We have examined whether genetic polymorphisms at the genes encoding chemokines , and and chemokine receptors ) and were associated with sporadic PD risk in Isparta, Turkey. . The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. Their genotype and haplotype frequencies were compared statistically. . One SNP in revealed a significant association with PD ( (allele) < 0.0001, -trend = 0.0007). The risk allele in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86-347.24 and 1.74-591.937, resp.) suggests additional PD risk. The haplotype from the , and has protective effect (OR = 0.08 [CI = 0.01-0.63], = 0.019). . Our data are the first indication of the role of in PD risk.
近期研究表明，炎症过程参与帕金森病（PD）的发病机制。多条证据表明趋化因子及其受体与多种神经退行性疾病有关。我们研究了趋化因子基因、和趋化因子受体基因及的基因多态性是否与土耳其伊斯帕尔塔的散发性PD风险相关。该初步病例对照关联研究纳入了30例PD患者和60例对照受试者，对这五个多态性均采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）进行基因分型。对他们的基因型和单倍型频率进行统计学比较。基因中的一个单核苷酸多态性（SNP）与PD存在显著关联（（等位基因）<0.0001，趋势=0.0007）。纯合子和显性模型中的风险等位基因提示额外的PD风险（OR分别为17.29和32.10，95%CI分别为0.86-347.24和1.74-591.937）。来自、和的单倍型具有保护作用（OR=0.08[CI=0.01-0.63]，=0.019）。我们的数据首次表明在PD风险中的作用。
