睾酮替代疗法与排尿功能障碍。
Testosterone replacement therapy and voiding dysfunction.
作者信息
Baas Wesley, Köhler Tobias S
机构信息
Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.
出版信息
Transl Androl Urol. 2016 Dec;5(6):890-897. doi: 10.21037/tau.2016.08.11.
Abstract
Testosterone replacement therapy (TRT) represents an increasing popular treatment option for men with late-onset hypogonadism (LOH). Because of unsubstantiated beliefs of testosterone's effect on the prostate, the FDA has recently placed a warning on testosterone products, stating that TRT may worsen benign prostatic hyperplasia (BPH). Within this review article we have demonstrated the current understanding of the physiology of testosterone and its relationship with prostatic and lower urinary tract physiology. The current evidence suggests that not only does TRT not worsen lower urinary tract symptoms (LUTS), but that hypogonadism itself is an important risk factor for LUTS/BPH.
摘要
睾酮替代疗法（TRT）对于迟发性性腺功能减退（LOH）男性而言，正成为一种越来越受欢迎的治疗选择。由于对睾酮对前列腺影响的无端认知，美国食品药品监督管理局（FDA）最近已在睾酮产品上发布警告，称TRT可能会使良性前列腺增生（BPH）恶化。在这篇综述文章中，我们阐述了目前对睾酮生理学及其与前列腺和下尿路生理学关系的理解。目前的证据表明，TRT不仅不会使下尿路症状（LUTS）恶化，而且性腺功能减退本身就是LUTS/BPH的一个重要风险因素。
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