Kawahara Takashi, Ninomiya Sahoko, Takeshima Teppei, Saito Tomoki, Ito Hiroki, Komeya Mitsuru, Hasumi Hisashi, Yumura Yasushi, Makiyama Kazuhide, Uemura Hiroji
Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama 232-0024, Japan.
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
J Clin Med. 2023 Dec 6;12(24):7528. doi: 10.3390/jcm12247528.
Late-onset hypogonadism (LOH) is a condition caused by the decline of testosterone levels with aging and is associated with various symptoms, including lower urinary tract symptoms (LUTSs). Although some reports have shown that testosterone replacement treatment for LOH improves LUTSs, no large study has revealed a correlation between LUTSs and LOH. This study investigated the correlation between the severity of LOH and LUTSs in Japanese males >40 years of age using a web-based questionnaire with the Aging Males' Symptoms (AMS) scale.
We asked 2000 Japanese males to answer both the AMS and IPSS/QOL questionnaires using a web-based survey. Among these 2000 individuals, 500 individuals were assigned to each age group.
The IPSS total score was positively correlated with the severity of AMS (shown as median [mean ± SD]): no/little group, 2 (3.67 ± 5.36); mild group, 6 (7.98 ± 6.91); moderate group, 11 (12.49 ± 8.63); and severe group, 16 (14.83 ± 9.24) ( < 0.0001).
Individuals with higher AMS values, representing cases with severe LOH symptoms, had a higher risk of experiencing nocturia and LUTSs than those with lower AMS values.
迟发性性腺功能减退（LOH）是一种因睾酮水平随年龄增长而下降所导致的病症，与多种症状相关，包括下尿路症状（LUTSs）。尽管一些报告显示，针对LOH的睾酮替代治疗可改善LUTSs，但尚无大型研究揭示LUTSs与LOH之间的关联。本研究使用基于网络的问卷调查及老年男性症状（AMS）量表，调查了40岁以上日本男性中LOH严重程度与LUTSs之间的相关性。
我们通过基于网络的调查，让2000名日本男性回答AMS问卷和国际前列腺症状评分/生活质量（IPSS/QOL）问卷。在这2000名个体中，每个年龄组分配500人。
IPSS总分与AMS严重程度呈正相关（以中位数[均值±标准差]表示）：无/轻度组，2（3.67±5.36）；轻度组，6（7.98±6.91）；中度组，11（12.49±8.63）；重度组，16（14.83±9.24）（<0.0001）。
AMS值较高的个体代表LOH症状严重，与AMS值较低的个体相比，其出现夜尿症和LUTSs的风险更高。
