Kim Soyoun, Samanta Palas, Yoo Jisu, Kim Woo-Keun, Jung Jinho
Division of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea.
System Toxicology Research Center, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.
Bull Environ Contam Toxicol. 2017 Apr;98(4):502-507. doi: 10.1007/s00128-016-2022-1. Epub 2017 Jan 11.
Aggregation and dissolution of CuO and ZnO nanoparticles (NPs) increased with increasing exposure time (24, 48, and 72 h). Acute toxicity of CuO NPs to Daphnia magna also increased significantly with increasing exposure time (p < 0.05), whereas exposure time did not significantly affect acute toxicity of ZnO NPs. The dissolved Cu concentration of CuO NPs was much lower than the median effective concentration (EC) value (44 μg L at 72 h), implying that the increase in acute toxicity was caused by particles rather than by dissolved ions. However, the dissolved Zn concentration of ZnO NPs was higher than the EC value (600 μg L at 72 h), suggesting this acute toxicity may be caused by dissolved ions. Moreover, CuO NPs induced greater lipid peroxidation than Cu ions did at an exposure time of 72 h, whereas converse results were observed for ZnO NPs.
随着暴露时间（24、48和72小时）的增加，氧化铜和氧化锌纳米颗粒（NPs）的聚集和溶解也随之增加。氧化铜纳米颗粒对大型溞的急性毒性也随着暴露时间的增加而显著增加（p < 0.05），而暴露时间对氧化锌纳米颗粒的急性毒性没有显著影响。氧化铜纳米颗粒的溶解铜浓度远低于半数有效浓度（EC）值（72小时时为44μg/L），这意味着急性毒性的增加是由颗粒而非溶解离子引起的。然而，氧化锌纳米颗粒的溶解锌浓度高于EC值（72小时时为600μg/L），表明这种急性毒性可能是由溶解离子引起的。此外，在暴露72小时时，氧化铜纳米颗粒比铜离子诱导了更大的脂质过氧化，而氧化锌纳米颗粒则观察到相反的结果。
