Cantore S, Ballini A, Mori G, Dibello V, Marrelli M, Mirgaldi R, De Vito D, Tatullo M
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Department of Clinical and Experimental Medicine, Medical School, University of Foggia, Italy.
J Biol Regul Homeost Agents. 2016 Oct-Dec;30(4):1173-1178.
The idea of incorporating a mouthrinse with normal tooth brushing could be a useful adjunct to oral hygiene. Despite the principle nature of the toothpaste vehicle, most alcohol-based chemical plaque-control agents have been evaluated and later formulated in the mouthrinse vehicle. The current study was aimed to investigate the persistence of antimicrobial action and plaque inhibitory properties of a new alcohol-free mouthrinse when compared with positive control, chlorhexidine 0.12% and placebo control, physiologic saline solution mouthrinses. The evaluation of the antimicrobial activity was performed by saliva samples collected during the 3 days of usage. The results of this study indicate that this new oral rinse has an equivalent plaque inhibitory action to chlorhexidine, and the plaque inhibitory action of the rinse appears to be derived from a persistence of antimicrobial action in the mouth. Furthermore, no side effects were reported during the study, and the additional benefit of no alcohol presence in the rinse solution.
将漱口水与常规刷牙相结合的想法可能是口腔卫生的一种有用辅助手段。尽管牙膏载体具有主要性质，但大多数基于酒精的化学菌斑控制剂已被评估并随后制成漱口水载体。本研究旨在调查一种新型无酒精漱口水与阳性对照0.12%氯己定和安慰剂对照生理盐水漱口水相比的抗菌作用持久性和菌斑抑制特性。抗菌活性评估通过使用3天期间收集的唾液样本进行。本研究结果表明，这种新型口腔漱口水具有与氯己定相当的菌斑抑制作用，且漱口水的菌斑抑制作用似乎源于口腔中抗菌作用的持久性。此外，研究期间未报告任何副作用，且漱口水溶液中不含酒精还有额外益处。
