Leung Alexander K C, Barankin Benjamin, Hon Kam L E
The University of Calgary, Alberta Children's Hospital, #200, 233 - 16th Avenue NW, Calgary, Alberta. Canada.
Toronto Dermatology Centre, Toronto, Ontario. Canada.
Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):2-11. doi: 10.2174/1872213X11666170110162344.
Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition.
To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans.
A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans". The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Patents were searched using the key term "cutaneous larva migrans" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com.
Cutaneous larva migrans is a zoonotic infestation caused by penetration and migration in the epidermis of filariform larva of different kinds of animal hookworms through contact with feces of infected animals. Cutaneous larva migrans is endemic in tropical and subtropical regions. Clinically, cutaneous larva migrans is characterized by an intensely pruritic erythematous migrating tortuous or serpiginous, slightly raised track. The diagnosis is mainly clinical, based on the history of travel to an endemic area and exposure to contaminated soil/sand and the characteristic serpiginous track. Treatment options as well as recent patents related to the management of cutaneous larva migrans are also discussed. Compared with oral antihelminthics, topical treatment over the affected area is less effective. Oral ivermectin is the treatment of choice.
The pruritic serpiginous track is pathognomonic. Oral ivermectin is the treatment of choice.
皮肤幼虫移行症是热带地区归国旅行者中报告的最常见皮肤病之一。然而，西方医生通常对这种疾病并不熟悉。
深入综述皮肤幼虫移行症的流行病学、病理生理学、临床表现、并发症及治疗。
在临床查询中使用关键词“皮肤幼虫移行症”完成PubMed检索。检索包括荟萃分析、随机对照试验、临床试验及综述。使用关键词“皮肤幼虫移行症”在www.google.com/patents、www.uspto.gov和www.freepatentsonline.com上检索专利。
皮肤幼虫移行症是一种人畜共患寄生虫感染，由不同种类动物钩虫的丝状幼虫通过接触受感染动物的粪便穿透并在表皮内移行所致。皮肤幼虫移行症在热带和亚热带地区呈地方性流行。临床上，皮肤幼虫移行症的特征为伴有强烈瘙痒的红斑性、迂曲或匐行性、略隆起的移行轨迹。诊断主要基于临床，依据前往流行地区的旅行史、接触受污染土壤/沙子的情况以及特征性的匐行轨迹。还讨论了皮肤幼虫移行症的治疗选择以及与管理相关的近期专利。与口服抗蠕虫药相比，在患处进行局部治疗效果较差。口服伊维菌素是首选治疗方法。
瘙痒性匐行轨迹具有诊断特异性。口服伊维菌素是首选治疗方法。
