Duschet P, Schwarz T, Gschnait F
Dermatologische Abteilung, im Krankenhaus der Stadt Wien-Lainz.
Hautarzt. 1989 Sep;40(9):553-5.
Plasmapheresis represents a new and powerful treatment for solar urticaria and has been performed in a couple of patients so far. Since therapeutic responses have been observed exclusively in cases exhibiting a pathogenetically important serum factor, plasmapheresis seems to work specifically by elimination of this photoallergen. It is easy to demonstrate a serum factor by in vitro irradiation of the patient's serum and subsequent autologous reinjection into the skin, inducing the generation of wheals. In contrast to transfer tests, this method does not bear the risk of HIV infection. In view of the extreme difficulty in administering conventional therapy for solar urticaria, the present encouraging results suggest that plasmapheresis should be considered in patients who show a serum factor.
血浆置换是治疗日光性荨麻疹的一种全新且有效的方法，目前已应用于少数患者。由于仅在出现具有致病重要性血清因子的病例中观察到治疗反应，血浆置换似乎是通过清除这种光变应原而发挥特异性作用。通过对患者血清进行体外照射，随后将其自体重新注入皮肤诱发风团形成，很容易证明血清因子的存在。与转移试验相比，该方法不存在感染艾滋病毒的风险。鉴于日光性荨麻疹常规治疗极其困难，目前令人鼓舞的结果表明，对于显示有血清因子的患者应考虑采用血浆置换疗法。
