Leenutaphong V, von Kries R, Hölzle E, Plewig G
Department of Dermatology, University of Düsseldorf, FRG.
Photodermatol. 1988 Aug;5(4):170-4.
A 17-year-old male with solar urticaria is described. The action spectrum ranged from 400 to 520 nm. Wheals induced by visible light were inhibited by simultaneous or subsequent irradiation of the skin with UVA radiation. UVA irradiation prior to exposure to eliciting wavelengths revealed no inhibitory effect, nor was an inhibitory effect found by pre- or postirradiation of test sites with visible light longer than 530 nm. In vitro activation of the patient's serum by exposure to visible light induced wheal formation at the injection site. The wheal formed by in vitro-activated serum was suppressed only when the serum was exposed to UVA after, but not before irradiation with wavelengths of the action spectrum. This suggests that the inactivation of a photoallergen rather than of its precursor is the mechanism by which UVA exerts an inhibitory effect.
本文描述了一名患有日光性荨麻疹的17岁男性患者。其作用光谱范围为400至520纳米。可见光诱发的风团可被同时或随后用UVA照射皮肤所抑制。在暴露于诱发波长之前进行UVA照射未显示出抑制作用，用波长大于530纳米的可见光对试验部位进行照射前或照射后也未发现抑制作用。通过暴露于可见光对患者血清进行体外激活可在注射部位诱发风团形成。仅当体外激活的血清在作用光谱波长照射后而非照射前暴露于UVA时，所形成的风团才会受到抑制。这表明UVA发挥抑制作用的机制是光变应原而非其前体的失活。
