慢性丙型肝炎患者中维生素D与肝纤维化之间存在关联吗？
Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?
作者信息
Oliveira Kalinca da Silva, Buss Caroline, Tovo Cristiane Valle
机构信息
Programa de Pós-graduação em Hepatologia da Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brasil.
Departamento de Nutrição da UFCSPA, RS, Brasil.
出版信息
Arq Gastroenterol. 2017 Jan-Mar;54(1):57-59. doi: 10.1590/S0004-2803.2017v54n1-11.
Abstract
BACKGROUND
- Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease.
OBJECTIVE
- This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection.
METHODS
- Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study.
RESULTS
- Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269).
CONCLUSION
- In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.
摘要
背景
维生素D以其免疫调节、抗炎和抗纤维化特性而闻名，这些特性在许多慢性肝病病因的发病机制和治疗中具有重要意义。
目的
本研究旨在评估慢性丙型肝炎病毒感染患者血清维生素D水平与组织病理学结果之间的关联。
方法
对慢性丙型肝炎患者进行横断面研究。所有患者均接受维生素D 25剂量和人体测量数据分析。在纳入研究前的最长36个月期间进行肝活检。
结果
在纳入研究的74例患者中，45例（60.8%）为女性，平均年龄为57.03±9.24岁，63例（85.1%）为白人。未观察到维生素D血清水平与炎症活动之间的关联（P=0.699），也未观察到与肝纤维化程度之间的关联（P=0.269）。
结论
在本研究中，未观察到慢性丙型肝炎患者维生素D与炎症活动以及肝纤维化程度之间的关联。
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