Simavli Huseyin, Poon Linda Yi-Chieh, Que Christian J, Liu Yingna, Akduman Mustafa, Tsikata Edem, de Boer Johannes F, Chen Teresa C
*Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA †Department of Ophthalmology, School of Medicine, Pamukkale University, Denizli, Turkey ‡Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung Taiwan §Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands.
J Glaucoma. 2017 Jun;26(6):592-601. doi: 10.1097/IJG.0000000000000621.
To determine the diagnostic capability of spectral domain optical coherence tomography peripapillary retinal volume (RV) measurements.
A total of 156 patients, 89 primary open-angle glaucoma and 67 normal subjects, were recruited. Spectral domain optical coherence tomography peripapillary RV was calculated for 4 quadrants using 3 annuli of varying scan circle diameters: outer circumpapillary annuli of circular grids 1, 2, and 3 (OCA1, OCA2, OCA3). Area under the receiver operating characteristic curves and pairwise comparisons of receiver operating characteristic (ROC) curves were performed to determine which quadrants were best for diagnosing primary open-angle glaucoma. The pairwise comparisons of the best ROC curves for RV and retinal nerve fiber layer (RNFL) were performed. The artifact rates were analyzed.
Pairwise comparisons showed that the smaller annuli OCA1 and OCA2 had better diagnostic performance than the largest annulus OCA3 (P<0.05 for all quadrants). OCA1 and OCA2 had similar diagnostic performance, except for the inferior quadrant which was better for OCA1 (P=0.0033). The pairwise comparisons of the best ROC curves for RV and RNFL were not statistically significant. RV measurements had lower rates of artifacts at 7.4% while RNFL measurements had higher rates at 42.9%.
Peripapillary RV measurements have excellent ability for diagnosing not only glaucoma patients but also a subset of early glaucoma patients. The inferior quadrant of peripapillary annulus OCA1 demonstrated the best diagnostic capability for both glaucoma and early glaucoma. The diagnostic ability of RV is comparable with that of RNFL parameters in glaucoma but with lower artifact rates.
确定频域光学相干断层扫描测量视乳头周围视网膜体积（RV）的诊断能力。
共招募了156名患者，其中89例原发性开角型青光眼患者和67名正常受试者。使用3个不同扫描圆直径的环带，计算4个象限的频域光学相干断层扫描视乳头周围RV：圆形网格1、2和3的外周视乳头环带（OCA1、OCA2、OCA3）。进行受试者操作特征曲线下面积分析以及受试者操作特征（ROC）曲线的成对比较，以确定哪些象限最适合诊断原发性开角型青光眼。对RV和视网膜神经纤维层（RNFL）的最佳ROC曲线进行成对比较。分析伪像率。
成对比较显示，较小的环带OCA1和OCA2的诊断性能优于最大的环带OCA3（所有象限P<0.05）。OCA1和OCA2具有相似的诊断性能，但下方象限OCA1的诊断性能更好（P = 0.0033）。RV和RNFL的最佳ROC曲线的成对比较无统计学意义。RV测量的伪像率较低，为7.4%，而RNFL测量的伪像率较高，为42.9%。
视乳头周围RV测量不仅对青光眼患者，而且对一部分早期青光眼患者具有出色的诊断能力。视乳头环带OCA1的下方象限对青光眼和早期青光眼均显示出最佳诊断能力。在青光眼诊断中，RV的诊断能力与RNFL参数相当，但伪像率较低。
