沙眼衣原体和生殖支原体检测呈阴性的非淋菌性尿道炎男性的女性伴侣是否应被告知并接受治疗？一项针对患有非淋菌性尿道炎的异性恋男性伴侣研究的临床结果

Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU.

作者信息

Ong Jason J, Sarumpaet Angela, Chow Eric P F, Bradshaw Catriona, Chen Marcus, Read Tim, Fairley Christopher K

机构信息

From the *Melbourne Sexual Health Centre, Alfred Health, Carlton; and †Central Clinical School, Monash University, Clayton, Victoria, Australia.

出版信息

Sex Transm Dis. 2017 Feb;44(2):126-130. doi: 10.1097/OLQ.0000000000000546.

DOI:10.1097/OLQ.0000000000000546

PMID:28079749

Abstract

BACKGROUND

To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection.

METHODS

Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. trachomatis (n = 176); 3) men with urethral M. genitalium (n = 26); and 4) asymptomatic men (n = 652).

RESULTS

Female partners of men with pathogen-negative NGU experienced deep pelvic pain (adjusted odds ratio [AOR], 2.2; 95% confidence interval [CI], 1.1-4.4), post coital bleeding (AOR, 2.4; 95% CI, 1.2-4.9), and dysuria (AOR, 3.7; 95% CI, 1.6-8.6) more commonly and were diagnosed with PID more commonly (AOR, 4.8; 95% CI, 2.1-11.3) than the female partners of asymptomatic men. Pelvic inflammatory disease was not more likely to be diagnosed in the female partners of men with genital warts (AOR, 1.4; 95% CI, 0.5-4.4) or candidiasis (AOR, 1.2; 95% CI, 0.4-3.5) than the female partners of asymptomatic men. The female partners of men with chlamydia experienced post coital bleeding more (AOR, 1.9; 95% CI, 1.0-3.6) and were more likely to be diagnosed with PID (AOR, 3.6; 95% CI, 1.6-8.0).

CONCLUSIONS

The female partners of men with pathogen-negative NGU may be at increased risk of genital infection, even if a recognised pathogen is not identified in the man.

摘要

背景

确定病原体阴性的非淋菌性尿道炎（NGU）男性患者的女性伴侣是否有生殖器感染风险。

方法

利用墨尔本一家大型性传播疾病诊所2006年1月至2015年4月期间同一天就诊的1710名男性及其女性伴侣的健康记录进行二次数据分析。确定以下几组女性伴侣中出现提示生殖器感染或盆腔炎（PID）症状的比例：（1）患有NGU且无沙眼衣原体或生殖支原体（称为病原体阴性NGU）的男性（n = 91）；2）尿道沙眼衣原体感染男性（n = 176）；3）尿道生殖支原体感染男性（n = 26）；4）无症状男性（n = 652）。

结果

与无症状男性的女性伴侣相比，病原体阴性NGU男性的女性伴侣更常出现深部盆腔疼痛（调整优势比[AOR]，2.2；95%置信区间[CI]，1.1 - 4.4）、性交后出血（AOR，2.4；95% CI，1.2 - 4.9）和排尿困难（AOR，3.7；95% CI，1.6 - 8.6），且更常被诊断为PID（AOR，4.8；95% CI，2.1 - 11.3）。与无症状男性的女性伴侣相比，尖锐湿疣男性（AOR，1.4；95% CI，0.5 - 4.4）或念珠菌病男性（AOR，1.2；95% CI，0.4 - 3.5）的女性伴侣被诊断为PID的可能性并不更高。衣原体感染男性的女性伴侣性交后出血更多见（AOR，1.9；95% CI，1.0 - 3.6），且更有可能被诊断为PID（AOR，3.6；95% CI，1.6 - 8.0）。