Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, P.R. China.
Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1898-1902. doi: 10.1002/anie.201611697. Epub 2017 Jan 12.
A palladium-catalyzed three-component reaction between fluoroalkyl bromides, arylboronic acids, and alkenyl aldehydes has been developed and provides facile access to 5-, 6-, or 7-difluoroalkylated ketones under very mild reaction conditions. The resultant products can be smoothly converted into CF -containing tetrahydronaphthalenes by a novel silver-catalyzed intramolecular decarboxylative cyclization of 5-aryl-2,2-difluoropentanoic acids.
钯催化的氟烷基溴、芳基硼酸和烯基醛之间的三组分反应已经被开发出来，并在非常温和的反应条件下提供了 5-、6-或 7-二氟烷基化酮的简便途径。通过新型银催化的 5-芳基-2,2-二氟戊酸的分子内脱羧环化，可以将得到的产物很容易地转化为含 CF 的四氢萘。
