通过钯催化的乙烯基异氰化物与溴二氟乙酸衍生物的自由基级联二氟烷基化-环化反应合成1-二氟烷基异喹啉
Synthesis of 1-Difluoroalkylated Isoquinolines via Palladium-Catalyzed Radical Cascade Difluoroalkylation-Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives.
作者信息
Liu Yingle, Zhang Ke, Jiang Weidong, Yang Yi, Jiang Yan, Liu Xiaoqiang, Xie Ying, Wu Jincai, Cai Junjie, Xu Xiu-Hua
机构信息
School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China.
出版信息
Chem Asian J. 2017 Mar 2;12(5):568-576. doi: 10.1002/asia.201601645. Epub 2017 Feb 8.
A general method was developed for the synthesis of 1-difluoroalkyl isoquinolines via the palladium-catalyzed radical cascade difluoroalkylation-cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. The difluoroalkylated cyclization products were readily converted to various other valuable gem-difluoro-containing compounds.
通过钯催化乙烯基异腈与溴二氟乙酸衍生物的自由基串联二氟烷基化-环化反应，开发了一种合成1-二氟烷基异喹啉的通用方法。二氟烷基化环化产物可很容易地转化为各种其他有价值的含偕二氟的化合物。
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