Gupta Suruchi, Gupta Nikhil
Medical Officer in the Department of Obstetrics and Gynecology at the Vardhman Mahavir Medical College and Safdarjung Hospital in Delhi, New Delhi, India.
Fellow in Clinical Immunology & Rheumatology at the Christian Medical College in Vellore, India.
Perm J. 2017;21:16-047. doi: 10.7812/TPP/16-047. Epub 2016 Nov 9.
Autoimmune diseases do not impair fertility, and women with autoimmune diseases who become pregnant are likely to experience more complicated pregnancies than are women without the disease. Pregnancies complicated by these disorders have a high clinical impact on both the pregnancy and the disease. The effect of autoimmune disease on pregnancy differs according to the type of maternal disease, disease activity, severity of organ damage, antibody profile, and drug treatment. Sjögren syndrome is an autoimmune disease with a high prevalence of anti-SS-A (anti-Ro) and anti-SS-B (anti-La) antibodies. Anti-SS-A antibodies are associated with congenital heart block. Data on pregnancy outcomes in primary Sjögren syndrome are scarce.
We performed a review of the literature regarding pregnancy outcomes in women with Sjögren syndrome.
Women with Sjögren syndrome are likely to experience more complications during pregnancy than women without an autoimmune disease. Studies show a high incidence of poor fetal outcomes for these patients.
Women with Sjögren syndrome require prenatal counseling explaining the risks involved and the need to control the disease well before conception. High-risk pregnancies can be optimally managed by a multidisciplinary team.
自身免疫性疾病不会损害生育能力，患有自身免疫性疾病的孕妇可能比未患该病的孕妇经历更复杂的妊娠过程。这些疾病所导致的复杂妊娠对妊娠和疾病都有很高的临床影响。自身免疫性疾病对妊娠的影响因母体疾病类型、疾病活动度、器官损害严重程度、抗体谱及药物治疗而异。干燥综合征是一种自身免疫性疾病，抗SS - A（抗Ro）和抗SS - B（抗La）抗体的患病率很高。抗SS - A抗体与先天性心脏传导阻滞有关。原发性干燥综合征的妊娠结局数据稀缺。
我们对有关干燥综合征女性妊娠结局的文献进行了综述。
与无自身免疫性疾病的女性相比，干燥综合征女性在妊娠期间可能会经历更多并发症。研究表明这些患者胎儿不良结局的发生率很高。
患有干燥综合征的女性需要接受产前咨询，了解其中涉及的风险以及在受孕前良好控制疾病的必要性。高危妊娠可由多学科团队进行最佳管理。
