Jung Yu Ra, Lee Jin-Hyup, Sohn Kyung-Cheol, Lee Young, Seo Young-Joon, Kim Chang-Deok, Lee Jeung-Hoon, Hong Seung-Phil, Seo Seong-Jun, Kim Seong-Jin, Im Myung
Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea.
Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea.
PLoS One. 2017 Jan 12;12(1):e0169824. doi: 10.1371/journal.pone.0169824. eCollection 2017.
Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that human sebaceous glands in vivo and sebocytes in vitro express adiponectin receptor and that adiponectin increased cell proliferation. Moreover, based on a lipogenesis study using Oil Red O, Nile red staining and thin layer chromatography, adiponectin strongly upregulated lipid production in sebocytes. In three-dimensional culture of sebocytes, lipid synthesis was markedly enhanced in sebocytes treated with adiponectin. This study suggested that adiponectin plays a significant role in human sebaceous gland biology. Adiponectin signaling is a promising target in the clinical management of barrier disorders in which sebum production is decreased, such as in atopic dermatitis and aged skin.
脂联素在代谢功能、炎症以及各种组织中的多种生物学活性中发挥着重要作用。然而，皮脂腺中脂联素信号传导的证据尚缺，其作用仍有待阐明。本研究在一项关于人皮脂腺细胞的实验研究中，探究了脂联素在皮脂腺脂质生成中的作用。我们证明，体内的人皮脂腺和体外的皮脂腺细胞表达脂联素受体，且脂联素能增加细胞增殖。此外，基于使用油红O、尼罗红染色和薄层色谱法进行的脂肪生成研究，脂联素强烈上调了皮脂腺细胞中的脂质生成。在皮脂腺细胞的三维培养中，用脂联素处理的皮脂腺细胞的脂质合成明显增强。本研究表明，脂联素在人类皮脂腺生物学中发挥着重要作用。脂联素信号传导是临床治疗屏障功能障碍（如特应性皮炎和老年皮肤中皮脂分泌减少）的一个有前景的靶点。
