Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Front Immunol. 2023 Jan 24;14:1116548. doi: 10.3389/fimmu.2023.1116548. eCollection 2023.
The skin contributes critically to health its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity. The integrity and effectiveness of skin barrier immunity strongly depends on the close interplay and communication between immune cells and the skin environment. Skin-associated adipocytes have been recognized to play a significant role in modulating skin immune responses and infection by secreting cytokines, adipokines, and antimicrobial peptides. This review summarizes the recent understanding of the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.
皮肤对健康至关重要，它是抵御多种外部病原体的屏障组织。皮肤的屏障功能在很大程度上取决于最上层的表皮层，表皮层由皮肤屏障免疫来加强。皮肤屏障免疫的完整性和有效性强烈依赖于免疫细胞和皮肤环境之间的紧密相互作用和交流。皮肤相关脂肪细胞通过分泌细胞因子、脂肪因子和抗菌肽，被认为在调节皮肤免疫反应和感染方面发挥着重要作用。本文综述了皮肤相关脂肪细胞与其他皮肤细胞在维持皮肤屏障免疫的完整性和有效性方面相互作用的最新认识。
