Department of Chest Diseases, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey.
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey.
Turk J Med Sci. 2016 Dec 20;46(6):1871-1874. doi: 10.3906/sag-1601-87.
BACKGROUND/AIM: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients.
Fifty-nine patients with systemic sclerosis (SSc) were enrolled in the study. We used high-resolution computed tomography for diagnosis and used DLCO to evaluate degree of lung involvement. Complete blood cell counts and acute phase reactants were included as laboratory assessments.
NLR values were significantly higher in the SSc-ILD group (3.66 ± 1.32 vs. 2.85 ± 1.12, P = 0.01) and correlated negatively with KCO. The NLR cut-off value was 3.21, its sensitivity was 81%, and its specificity was 81%.
NLR level may serve as a marker of lung involvement in the presence of ILD in patients with SSc.
背景/目的：系统性硬化症相关间质性肺病（SSc-ILD）的严重程度基于临床和影像学发现、炎症标志物水平以及肺一氧化碳弥散量（DLCO）。目前，正在进行针对客观和简便标志物的研究。中性粒细胞/淋巴细胞比值（NLR）在最近的临床试验中被证明是炎症的良好标志物。在这项研究中，我们旨在确定 NLR 与 SSc-ILD 患者的一氧化碳传递系数（KCO）之间可能的关系。
59 名系统性硬化症（SSc）患者入组本研究。我们使用高分辨率计算机断层扫描进行诊断，并使用 DLCO 评估肺受累程度。全血细胞计数和急性期反应物被纳入实验室评估。
SSc-ILD 组的 NLR 值明显更高（3.66 ± 1.32 比 2.85 ± 1.12，P = 0.01），且与 KCO 呈负相关。NLR 的截断值为 3.21，其灵敏度为 81%，特异性为 81%。
在 SSc 患者存在ILD 的情况下，NLR 水平可能是肺受累的标志物。
