Department of Dermatology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Department of Dermatology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Turk J Med Sci. 2016 Dec 20;46(6):1641-1644. doi: 10.3906/sag-1507-31.
BACKGROUND/AIM: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss.
The study cohort consisted of 19 patients with acne vulgaris. Noninvasive methods were used to measure the biophysical characteristics of forehead skin. All measurements were repeated following the completion of 3 months of systemic isotretinoin treatment.
Biophysical skin parameter measurements after 3 months of isotretinoin therapy revealed a decrease in the severity of seborrhea. However, the skin was dry, indicting a decrease in stratum corneum hydration. An increase in skin temperature was also determined.
Treatment with systemic isotretinoin reduces sebum secretion and stratum corneum hydration and increases skin temperature, suggesting that isotretinoin may partially improve the biophysical characteristics of the skin among patients with acne vulgaris.
背景/目的：近 30 年来，全身性异维 A 酸已被广泛认为是治疗严重和难治性痤疮的有效且安全的医学疗法。然而，它似乎也会引起不良的皮肤副作用。本研究的目的是前瞻性地测量寻常痤疮患者在接受异维 A 酸治疗 3 个月前后皮肤功能的生物物理参数，包括 pH 值、温度、皮脂含量、皮肤水分和经表皮水分流失。
研究队列包括 19 名寻常痤疮患者。使用非侵入性方法测量前额皮肤的生物物理特性。在完成 3 个月的全身性异维 A 酸治疗后，重复所有测量。
异维 A 酸治疗 3 个月后的皮肤生物物理参数测量显示皮脂分泌减少。然而，皮肤干燥，表明角质层水分减少。还确定了皮肤温度升高。
全身性异维 A 酸治疗可减少皮脂分泌和角质层水分，并增加皮肤温度，这表明异维 A 酸可能部分改善寻常痤疮患者的皮肤生物物理特性。
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