Veerappan Ganesan Asha Purnima, Eisenlohr Laurence C
Department of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States.
Department of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States.
Curr Opin Virol. 2017 Feb;22:71-76. doi: 10.1016/j.coviro.2016.11.009. Epub 2017 Jan 12.
By convention, CD4 T cells are activated predominantly by Major Histocompatibility Complex class II-bound peptides derived from extracellular (exogenous) antigens. It has been known for decades that alternative sources of antigen, particularly those synthesized within the antigen-presenting cell, can also supply peptides but the impact on T responses, sometimes considerable, has only recently become appreciated. This review focuses on the contributions that studies of viral antigen have made to this shift in perspective, concluding with discussions of relevance to rational vaccine design, autoimmunity and cancer immunotherapy.
按照惯例，CD4 T细胞主要由源自细胞外（外源性）抗原的主要组织相容性复合体II类结合肽激活。几十年来人们已经知道，抗原的替代来源，特别是那些在抗原呈递细胞内合成的来源，也可以提供肽，但对T细胞反应的影响，有时相当大，直到最近才得到重视。这篇综述重点关注病毒抗原研究对这一观点转变所做的贡献，并在最后讨论其与合理疫苗设计、自身免疫和癌症免疫治疗的相关性。
