Wang Dan, Zhai Jun-Xia, Liu Dian-Wu
Department of Epidemiology and Biostatistics, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Library, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China.
Department of Novelty Retrieval, Institute of Hebei Medical Information, Shijiazhuang 050071, Hebei Province, China.
Mol Cell Endocrinol. 2017 Mar 5;443:72-79. doi: 10.1016/j.mce.2017.01.006. Epub 2017 Jan 9.
The association between serum folate and vitamin B12 levels and the risk of diabetic peripheral neuropathy (DPN) remains unclear. This meta-analysis included 16 studies of serum folate levels (1190 cases and 1501 controls) and 18 studies of serum vitamin B12 levels (1239 cases and 1562 controls) in patients with type 2 diabetes mellitus (T2DM). Reduced serum levels of folate and vitamin B12 were found in patients with T2DM and DPN compared with patients with T2DM but without DPN; weighted mean difference (WMD) = -1.64 (95% confidence interval [CI] = -2.46, -0.81) and WMD = -70.86 (95% CI = -101.55, -40.17), respectively. A subgroup analysis confirmed these associations in the Chinese population, but not in the Caucasian and mixed populations. In conclusion, these findings support the need for further controlled studies in defined patient populations and the importance of monitoring serum folate and vitamin B12 levels in patients with T2DM.
血清叶酸和维生素B12水平与糖尿病周围神经病变（DPN）风险之间的关联仍不明确。这项荟萃分析纳入了16项关于2型糖尿病（T2DM）患者血清叶酸水平的研究（1190例病例和1501例对照）以及18项关于血清维生素B12水平的研究（1239例病例和1562例对照）。与无DPN的T2DM患者相比，T2DM合并DPN患者的血清叶酸和维生素B12水平降低；加权平均差（WMD）分别为-1.64（95%置信区间[CI]=-2.46，-0.81）和-70.86（95%CI=-101.55，-40.17）。亚组分析在中国人群中证实了这些关联，但在白种人和混合人群中未得到证实。总之，这些发现支持在特定患者群体中开展进一步对照研究的必要性，以及监测T2DM患者血清叶酸和维生素B12水平的重要性。
