Patel J B, Giles R E
ICI Pharmaceuticals Group, ICI Americas Inc., Wilmington, DE 19897.
J Antimicrob Chemother. 1989 Sep;24 Suppl A:307-9. doi: 10.1093/jac/24.suppl_a.307.
The proconvulsive tendency of the novel carbapenem, meropenem was compared to that of imipenem, alone and in combination with cilastatin. The potentiation of metrazole-induced convulsions in mice was measured. Both imipenem and imipenem/cilastatin caused significant potentiation of metrazole-induced convulsions at a dose of 200 mg/kg, i.v. In contrast, meropenem (50-400 mg/kg, iv) failed to exhibit any significant potentiation of metrazole-induced seizures.
