Dong Debo, Wang Yulin, Chang Xuebin, Jiang Yuchao, Klugah-Brown Benjamin, Luo Cheng, Yao Dezhong
Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Faculty of Psychological and Educational Sciences, Department of Experimental and Applied Psychology, Research Group of Biological Psychology, Vrije Universiteit Brussel, Brussels 1040, Belgium; Faculty of Psychology and Educational Sciences, Department of Data Analysis, Ghent University, Henri Dunantlaan 2, Ghent B-9000, Belgium.
Schizophr Res. 2017 Jul;185:41-50. doi: 10.1016/j.schres.2017.01.005. Epub 2017 Jan 9.
Patients with schizophrenia and bipolar disorder (BD) shared a significant overlap in genetic susceptibility, pharmacological treatment responses, neuropsychological deficits, and epidemiological features. However, it remains unknown whether these clinical overlaps are mediated by shared or disorder-specific abnormalities of white matter integrity. In this voxel-based meta-analytic comparison of whole-brain white matter integrity, we aimed to identify the shared or disorder-specific structural abnormalities between schizophrenia and BD. A comprehensive literature search was conducted up to February 2016 to identify studies that compared between patients and healthy controls (HC) by using whole-brain diffusion approach (schizophrenia: 24 datasets with 754 patients vs. 775 HC; BD: 23 datasets with 705 patients vs. 679 HC). Voxel-wise meta-analyses were conducted and restricted to unified template using seed-based d-Mapping. Abnormal white matter integrity was calculated within each condition and a direct comparison of effect size was performed of alterations between two conditions. Two regions with significant reductions of fractional anisotropy (FA) characterized abnormal water diffusion in both disorders: the genu of the corpus callosum (CC) and posterior cingulum fibers. There was no significant difference found between the two disorders. Our results highlighted shared impairments of FA at genu of the CC and left posterior cingulum fibers, which suggests that, phenotypic overlap between schizophrenia and BD could be related to common brain circuit dysfunction.
精神分裂症和双相情感障碍（BD）患者在遗传易感性、药物治疗反应、神经心理缺陷和流行病学特征方面存在显著重叠。然而，这些临床重叠是否由白质完整性的共同异常或特定疾病异常介导仍不清楚。在这项基于体素的全脑白质完整性荟萃分析比较中，我们旨在确定精神分裂症和双相情感障碍之间共同的或特定疾病的结构异常。截至2016年2月进行了全面的文献检索，以确定使用全脑扩散方法比较患者与健康对照（HC）的研究（精神分裂症：24个数据集，754例患者与775例HC；双相情感障碍：23个数据集，705例患者与679例HC）。进行了基于体素的荟萃分析，并使用基于种子的d映射限制在统一模板上。在每种情况下计算白质完整性异常，并对两种情况之间的改变进行效应大小的直接比较。两个分数各向异性（FA）显著降低的区域表征了两种疾病中异常的水扩散：胼胝体膝部（CC）和后扣带纤维。两种疾病之间未发现显著差异。我们的结果突出了CC膝部和左侧后扣带纤维处FA的共同损伤，这表明精神分裂症和双相情感障碍之间的表型重叠可能与常见的脑回路功能障碍有关。
