Burke P, Meyer V, Kocoshis S, Orenstein D M, Chandra R, Nord D J, Sauer J, Cohen E
J Am Acad Child Adolesc Psychiatry. 1989 Nov;28(6):948-51. doi: 10.1097/00004583-198911000-00022.
The lifetime and current prevalence of depression and anxiety disorders was determined in 41 children with Crohn's disease, 12 children with ulcerative colitis, and 52 children with cystic fibrosis, using the Kiddie-Schedule for Affective Disorders and Schizophrenia interview. The lifetime prevalence of depression was 29% in Crohn's disease, 21% in ulcerative colitis, and 11.5% in cystic fibrosis. The difference in the prevalence of depression between Crohn's disease and cystic fibrosis was significant (p less than 0.05). The lifetime and current prevalence of dysthymia was significantly greater in ulcerative colitis than Crohn's disease (p less than 0.01) or cystic fibrosis (p less than 0.01). The lifetime prevalence of atypical depression was significantly greater in Crohn's disease than cystic fibrosis (22% versus 5.8%, p less than 0.05) and was also greater in ulcerative colitis than cystic fibrosis (21% versus 5.8%, p = 0.1). There was no difference between the groups in the current prevalence of major depression or atypical depression, or in the lifetime or current prevalence of anxiety disorders.
采用儿童情感障碍和精神分裂症访谈量表，对41例克罗恩病患儿、12例溃疡性结肠炎患儿和52例囊性纤维化患儿的抑郁症和焦虑症终生患病率及现患率进行了测定。克罗恩病患儿抑郁症终生患病率为29%，溃疡性结肠炎患儿为21%，囊性纤维化患儿为11.5%。克罗恩病与囊性纤维化之间抑郁症患病率的差异具有统计学意义（p<0.05）。溃疡性结肠炎患儿心境恶劣障碍的终生患病率和现患率显著高于克罗恩病（p<0.01）或囊性纤维化（p<0.01）。克罗恩病患儿非典型抑郁症的终生患病率显著高于囊性纤维化（22%对5.8%，p<0.05），溃疡性结肠炎患儿也高于囊性纤维化（21%对5.8%，p=0.1）。各组在重度抑郁症或非典型抑郁症的现患率、焦虑症的终生患病率或现患率方面均无差异。
